Any NixOS users?

Has anyone here used NixOS for any significant amount of time as their daily driver? I've been considering using it since I learned about it, I really like the idea of how it manages packages, but I'm a bit hesitant, particularly about the availability of packages, and how the whole folder structure changes from the usual Linux. I'm also worried since I haven't seen any guide about how to use python other than the usual advice to get a virtualenv for everything.

I consider myself a fairly advanced Linux user, I have used Arch as my daily driver for 4 years, and Linux for like 10 years, as a side note, so I'm not really that afraid of troubleshooting.