A few interesting pieces of information for those without the scientific mind or time to read through the whole thing: This implies potential application of manipulating the gut biome as a way to...
Exemplary
A few interesting pieces of information for those without the scientific mind or time to read through the whole thing:
Propionibacterium, for example, is a genus capable of producing SCFAs, predominantly acetate and propionic acid. Propionic acid can exhibit a profound antimicrobial effect against USA300, the most prevailing community-acquired methicillin-resistant Staphylococcus aureus
This implies potential application of manipulating the gut biome as a way to treat serious and difficult bacterial infections such as MRSA.
Study design
Oral probiotic
Clinical response
Intervention group only; 300 subjects with acne
L. acidophilus and L. bulgaricus∗ (probiotic × 8 days, 2-weeks washout, then re-introduction × 8 days)
clinical improvement in 80% of patients, particularly those with inflammatory acne
↑ Recovery of skin immune homeostasis following UV-induced immunosuppression
Randomized, controlled, open-label; 45 females with acne
L. acidophilus (NAS), LB-51∗, B. bifidum, (5×109, 5×109, 20×109 CFU 2×/d × 12 weeks
Significant ↓ in number of acne lesions with using probiotic together with Abs than Abs alone
A lot of information in this table, but various double blind or large studies on probiotics showing treatment for skin conditions such as acne and dermatitis.
Research conducted by Poutahidis et al. (2013) found that mice experienced accelerated wound healing following the consumption of Lactobacillus reuteri. Microscopic examination of wounds throughout the healing process revealed the usual histomorphologic stages of wound healing in both probiotic-treated and untreated mice, however, the time required for complete healing was markedly reduced in the treated group.
Gut microbiome could be a way to increase the speed at which people recover from wounds. Potential application in hospital food, especially when combined with gut flora that might promote a hostile environment for MRSA and other serious infections common in hospitals?
Supporting this hypothesis is the frequent association of both psychological comorbidities – anxiety and depression – and GI distress with acne. These psychological stressors are hypothesized to cause the intestinal flora to either produce different neurotransmitters – serotonin, norepinephrine and acetylcholine – or trigger nearby enteroendocrine cells to release neuropeptides. These neurotransmitters not only increase intestinal permeability, leading to both intestinal and systemic inflammation, but also directly access the circulation through the compromised intestinal barrier resulting in systemic effects
They talk about the fairly well accepted brain/gut link and comorbidities of gut issues with depression (and other mental diseases). They then expand upon this to skin issues such as acne and propose a method in which this makes sense.
The diet-microbiome theory implies that the increased prevalence of allergic disease stems from a less robust state of immune homeostasis rather than from overresponse to innocuous environmental cues
The low fiber and high fat content characteristic of the western diet fundamentally changes the gut microbiome, resulting in deficient production of immunomodulatory metabolites, particularly SCFAs. SCFAs are known for their anti-inflammatory actions mediated by G-protein coupled receptor 43 and for their contribution to epithelial barrier integrity
Reduced local and systemic immune tolerance resulting from an altered gut microbiome may help explain the observed rise of both autoimmune and atopic disease observed in the western world
For a long time there's been an accepted hypothesis known as the "hygiene hypothesis" which is an explanation for why we have seen an increase in allergic and immuno related diseases. The idea is that a more sterile environment is why we see a stronger immune response in children today than we did in the past (think of how dirty things were 50+ years ago).
The authors point out that this fails to account for an increase in certain biological processes which are known contributors to an enhanced immune response and suggest that it's our diet, instead, that is causing the rise in these immune issues.
If you have the time and the scientific mind, I would highly suggest reading through the entirety of this journal article. If you've ever suffered from any skin conditions (in particular acne, dermatitis, or psoriasis), there's actual human trials that have been conducted on relatively easy to acquire probiotics which might help or ease your symptoms and educate you as to why it works. Obviously a lot of this is still very early in human trials, but this is something which can luckily be researched pretty quickly as we are talking about introducing cultures of bacteria we know already exist in humans as an effort to help re-balance our gut flora to promote healthiness. I'm quite excited to see how this field continues to develop and provide useful, actionable data.
I've heard the sentiment several times over the years that despite anecdotal accounts of changing what you eat or "cutting-out-thing-x" improving or worsening the condition of the skin, we didn't...
I've heard the sentiment several times over the years that despite anecdotal accounts of changing what you eat or "cutting-out-thing-x" improving or worsening the condition of the skin, we didn't really have enough data on this topic. The study is from 2018 and it seems like we're finally getting some more insight into how our diet and gut microbiome can affect our skin.
A few interesting pieces of information for those without the scientific mind or time to read through the whole thing:
This implies potential application of manipulating the gut biome as a way to treat serious and difficult bacterial infections such as MRSA.
A lot of information in this table, but various double blind or large studies on probiotics showing treatment for skin conditions such as acne and dermatitis.
Gut microbiome could be a way to increase the speed at which people recover from wounds. Potential application in hospital food, especially when combined with gut flora that might promote a hostile environment for MRSA and other serious infections common in hospitals?
They talk about the fairly well accepted brain/gut link and comorbidities of gut issues with depression (and other mental diseases). They then expand upon this to skin issues such as acne and propose a method in which this makes sense.
For a long time there's been an accepted hypothesis known as the "hygiene hypothesis" which is an explanation for why we have seen an increase in allergic and immuno related diseases. The idea is that a more sterile environment is why we see a stronger immune response in children today than we did in the past (think of how dirty things were 50+ years ago).
The authors point out that this fails to account for an increase in certain biological processes which are known contributors to an enhanced immune response and suggest that it's our diet, instead, that is causing the rise in these immune issues.
If you have the time and the scientific mind, I would highly suggest reading through the entirety of this journal article. If you've ever suffered from any skin conditions (in particular acne, dermatitis, or psoriasis), there's actual human trials that have been conducted on relatively easy to acquire probiotics which might help or ease your symptoms and educate you as to why it works. Obviously a lot of this is still very early in human trials, but this is something which can luckily be researched pretty quickly as we are talking about introducing cultures of bacteria we know already exist in humans as an effort to help re-balance our gut flora to promote healthiness. I'm quite excited to see how this field continues to develop and provide useful, actionable data.
What an excellent write-up, thank you very much for taking the time to do this.
I've heard the sentiment several times over the years that despite anecdotal accounts of changing what you eat or "cutting-out-thing-x" improving or worsening the condition of the skin, we didn't really have enough data on this topic. The study is from 2018 and it seems like we're finally getting some more insight into how our diet and gut microbiome can affect our skin.