Schnupfenheld's recent activity
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Comment on mRNA cancer vaccine reprograms immune system to tackle glioblastoma in ~science
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Comment on mRNA cancer vaccine reprograms immune system to tackle glioblastoma in ~science
Schnupfenheld LinkFound this to be an interesting article about a novel treatment that uses mRNA-technique to help activate the immune system toward special types of glioblastomas: Perhaps this has potential to...Found this to be an interesting article about a novel treatment that uses mRNA-technique to help activate the immune system toward special types of glioblastomas:
In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—immune cold, very few immune cells, very silenced immune response—to ‘hot,’ very active immune response.
Perhaps this has potential to open new doors to future effective cancer treatments, which would be quite exciting. And when powered by AI-implementation, things could maybe progress even faster? I found it to be a fascinating thought.
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mRNA cancer vaccine reprograms immune system to tackle glioblastoma
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Comment on Tildes Book Club - We will be discussing Piranesi the third week in April in ~books
Schnupfenheld LinkOne of my favorite books. I'm super excited to join in!One of my favorite books. I'm super excited to join in!
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Organizing self-hosted classical music collection
I'm currently using Navidrome to self-host my music collection, while using DSub to listen on-the-go. This works very well for most genres, except for the bulk of my music which is classical...
I'm currently using Navidrome to self-host my music collection, while using DSub to listen on-the-go.
This works very well for most genres, except for the bulk of my music which is classical music. This presents its own host of problems pertaining to cataloguing and using metadata, since there are often multiple recordings of the same musical composition, recorded by multiple conductors with different orchestras and/or soloists. There may also be different instrumental arrangements of the same musical piece. Merely sorting by "Artist" is therefore quite unsatisfactory in this scenario.
Some streaming services have come up with quite satisfying solutions in my experience (notably Apple Music Classical and Idagio), but I am not sure how to go about listening to my own self-hosted classical music.
Is anybody here on Tildes familiar with this organizational problem? I would be very eager to hear how you have tackled this. Is there any self-hosted software more suitable to cataloguing musical collections with extensive metadata?
13 votes -
Comment on Grateful Dead - listening suggestions in ~music
Schnupfenheld Link ParentWhat an amazing reply. I'm stunned. I asked for a map of the lands and this is exactly that in every possible way. I'm sure I'll come back to this post many times in the future. Thank you for...What an amazing reply. I'm stunned. I asked for a map of the lands and this is exactly that in every possible way.
I'm sure I'll come back to this post many times in the future. Thank you for taking the time to write this @arghdos, I really appreciate it!
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Grateful Dead - listening suggestions
Calling all Deadheads on Tildes! I've listened to the Grateful Dead sporadically throughout the years but never really took a deep dive. The incredible goldmine that is...
Calling all Deadheads on Tildes!
I've listened to the Grateful Dead sporadically throughout the years but never really took a deep dive. The incredible goldmine that is https://archive.org/details/GratefulDead is just waiting, mysterious and silently beckoning... but I have no map of the landscape so the question is, where to begin?
What are your favorite recordings?
Edit: Thank you all for your suggestions. I'm so eager to listen them all through!
12 votes
AI summary (from Universal Summarizer by Kagi)
Researchers at the University of Florida have developed an mRNA cancer vaccine that can rapidly reprogram the immune system to attack glioblastoma, the most aggressive and lethal type of brain tumor.
The vaccine uses the patient's own tumor cells to create a personalized vaccine, and a novel lipid particle delivery mechanism to enhance the immune response.
In a first-in-human clinical trial with 4 adult patients, the vaccine triggered a rapid and vigorous immune response against the tumor within 48 hours.
Preclinical studies in mice and a trial with 10 pet dogs with spontaneous brain tumors also showed the vaccine's ability to reprogram the tumor microenvironment and improve survival.
The vaccine aims to overcome the tumor's immunosuppressive effects and allow the activated immune cells to effectively fight the cancer.
The researchers plan to expand the clinical trial to include up to 24 adult and pediatric brain cancer patients to further validate the initial findings.
The vaccine represents a novel approach to cancer immunotherapy that simultaneously modulates both the innate and adaptive immune responses.
The rapid immune activation seen with the vaccine is an important finding, as it suggests the potential to overcome the initial immunosuppression that often limits the success of cancer immunotherapies.
The researchers hope the vaccine could be a new paradigm for cancer treatment and potentially synergize with other immunotherapies.
The successful translation of results from preclinical animal models to human patients is a significant achievement, highlighting the potential of this mRNA vaccine approach.