What are some great LGBT speculative fiction?

Speculative fiction contains elements that don't exist in reality. It includes genres such as science fiction, fantasy, and supernatural horror.

A producer friend is looking for stories with a focus on LGBT issues. As someone with a predilection for speculative fiction, it would be great to read/watch some speculative stories that deal with issues in that area. I am aware of some stories with LGBT characters, but gender and LGBT issues are generally not the main themes. I'd love to get suggestions for movies, TV shows, and books (especially short stories) that deal with those issues in a proper and inventive way.

As usual, Wikipedia has an extensive list on the subject, but I was hoping to get some more personal suggestions from the Tildes crowd.

Thanks!