16 votes

Not all sleep is equal when it comes to cleaning the brain

6 comments

  1. [2]
    patience_limited
    Link
    Sleep has been one of the least understood things that we spend a great deal of time and energy on. It's just fascinating that its functions are slowly becoming clear, illuminating why good sleep...

    Sleep has been one of the least understood things that we spend a great deal of time and energy on. It's just fascinating that its functions are slowly becoming clear, illuminating why good sleep is so crucial to well-being.

    Although this study doesn't look at depression, it's certainly interesting that ketamine and related drugs affect the previously unknown glymphatic system (discovered in 2012). The glymphatic system has its greatest activity during deep sleep, and is responsible for regulating fluids and removing waste from the brain.

    Most of us have experienced impaired sleep, of greater or lesser duration. Some of us have the dangerous cycle of poor quality sleep, exhaustion, depression, and further sleep impairment. It's hard to say which condition is the precursor of the other, but there's more than enough evidence that lack of good sleep is both short- and long-term bad for your health.

    Having an understandable mechanism suggests there will soon be a new array of drugs, prescribed widely. If glutamate metabolism in the brain regulates the glymphatic system, it explains the activity of some existing glutamatergic drugs - memantine (already used for Alzheimer's), acamprosol (used for treating alcohol abuse), and others.

    Esketamine is being released soon.

    I'm generally skeptical that quick-fix monkeying with the system controls is the best strategy in treating diseases rooted in chronic maladaptation to modern life. But bad sleep often leaves you without resources. We already know there are myriad external stressors, lifestyle factors, and cognitive processes involved. An effective short-term sleep treatment might be the lifesaver that helps long enough to change everything else.

    8 votes
    1. ThatFanficGuy
      Link Parent
      The last paragraph analyses the situation well. When you're drained, you're drained. It's not often that the luck strikes and you'd be able to turn things around. After you'd stopped digging the...

      The last paragraph analyses the situation well. When you're drained, you're drained. It's not often that the luck strikes and you'd be able to turn things around. After you'd stopped digging the hole, and before you start filling it back, a ladder would be useful to get out first.

      6 votes
  2. [4]
    xstresedg
    Link
    I hope it's alright to share a link here. This is from Dr. Rhonda Patrick's podcast where she had Dr. Matthew Walker, a Neuroscience and Psych Ph.D, on regarding a number of things but sleep and...

    I hope it's alright to share a link here. This is from Dr. Rhonda Patrick's podcast where she had Dr. Matthew Walker, a Neuroscience and Psych Ph.D, on regarding a number of things but sleep and the glymphatic system were big proponents of the conversation.

    https://www.foundmyfitness.com/episodes/matthew-walker

    I just listened to it yesterday, it was intriguing. I'll be checking out this article when I can, as well.

    4 votes
    1. patience_limited
      Link Parent
      It's absolutely all right to share links, as long as it's not something like a direct product promotion, or super-low effort spam/meme link, without content or context. That's a fascinating site,...

      It's absolutely all right to share links, as long as it's not something like a direct product promotion, or super-low effort spam/meme link, without content or context.

      That's a fascinating site, and you've just added to the height of my Reading Mountain. I'm really hoping that a reduction in job stress will let me sleep well enough again. I'd swear the past year has aged me ten, I can barely remember anything these days.

      2 votes
    2. [2]
      lazer
      Link Parent
      This is so interesting; I read Walker's book and it changed my approach to sleep (I now treat it as being just as important as diet and exercise), but listening to this makes me want to go further...

      This is so interesting; I read Walker's book and it changed my approach to sleep (I now treat it as being just as important as diet and exercise), but listening to this makes me want to go further and experiment with some of the memory retention concepts he talks about - such as experimenting with playing some audio during sleep to see how it might affect memory retention of a relevant concept learned earlier in the day.

      1 vote
      1. xstresedg
        Link Parent
        Just listening to Dr. Walker and Dr. Patrick really makes me want to delve deeper into the subject. Especially since I lack in multiple aspects of sleep haha.

        Just listening to Dr. Walker and Dr. Patrick really makes me want to delve deeper into the subject. Especially since I lack in multiple aspects of sleep haha.

        1 vote