Bigger, better models (often Transformer-based) are everywhere in biotech. They genuinely seem to be changing the state of the art in drug (and biologic) development. And it’s past time to do a serious review of what’s become available and what it can and can’t do.
AI optimists who aren’t familiar with biotech are often wildly miscalibrated about what AI tools can do even in the best case scenario.
The average approved drug in the US costs $879.3 million in R&D expenses (counting the costs of failed drugs), and nearly 90% of that is spent on clinical trials. It’s legally, scientifically, and ethically necessary to test drugs on humans to see if they’re safe and effective. And while the ballooning cost of running clinical trials is a problem worth tackling in itself, it’s inherently time- and labor-intensive to run valid experiments on human patients. An AI is never going to “design a drug” that you can give to patients right away. Even if the AI were a perfect all-knowing oracle, pharmaceutical companies would still need to run animal and then human trials.
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If the model tells you to do something you would probably have done anyway, it’s useless. If the model replaces something you would have needed to do manually, it’s somewhat useful. If the model increases your odds of a successful therapy, it’s extremely useful, and if it adds successful therapies it’s world-changing.
From the article:
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