Food for thought: I don't really have anything insightful to add, but I'm imagining smoking a cigarette and getting your ego totally obliterated by the combination of DMT, psilocin, and bufotenine.
Food for thought: I don't really have anything insightful to add, but I'm imagining smoking a cigarette and getting your ego totally obliterated by the combination of DMT, psilocin, and bufotenine.
That might be one helluva way to get someone to quit smoking. Or conversely, that's all they do from then on. Though could you imagine a pack a day of those? Oof.
That might be one helluva way to get someone to quit smoking.
Or conversely, that's all they do from then on. Though could you imagine a pack a day of those? Oof.
After coming down from the most intense trip of your life, you forget where and when (and who?) you are. You find a pack of cigarettes in your pocket, and having the urge you light one up and take...
After coming down from the most intense trip of your life, you forget where and when (and who?) you are. You find a pack of cigarettes in your pocket, and having the urge you light one up and take a drag...
“Magic mushrooms” make psilocybin. Tropical plants make the ingredients of the psychoactive ayahuasca. And toads secrete the mind-altering bufotenin. Now, the tobacco plant makes them all.
...
One reason for the success is that tobacco plants make abundant tryptophan, so there was no shortage of the starting material. This inspired Berman and Aharoni to try making other tryptophan-based psychoactives in tobacco, such as psilocybin and its precursor. They also tweaked the plants to produce bufotenin and 5-methoxy-DMT, hallucinogens that the Sonoran Desert toad (Incilius alvarius) secretes from glands behind its eyes.
I'm left to wonder, like for many things in life, what series of events leads people to learn something like the fact that the secretion from behind a toad's eye is hallucinogenic? ತ_ತ
I'm left to wonder, like for many things in life, what series of events leads people to learn something like the fact that the secretion from behind a toad's eye is hallucinogenic? ತ_ತ
Edit 38m: removed typos and repetitive passages If you look at the folklore/mythos behind these things, its usually a case of an early human seeing an animal acting strange after ingesting a...
Edit 38m: removed typos and repetitive passages
If you look at the folklore/mythos behind these things, its usually a case of an early human seeing an animal acting strange after ingesting a certain plant, like coffee or tobacco. In other cases, Caveman Fred eats a specific berry and dies, then his people create a story about how this type of bush or berry is cursed.
(At least that's what I remember from bits and pieces of research here and there.)
Going off what Queresote said, I'd be willing to bet that someone just ate a toad they caught at some point and had a really intense trip, and through trial and error they narrowed it down to the...
Going off what Queresote said, I'd be willing to bet that someone just ate a toad they caught at some point and had a really intense trip, and through trial and error they narrowed it down to the secretion coming from the eyes.
Nope, there is an actual academic article, and this is a well-known process of doing transgenics on organisms to use them as a tool for synthesizing some drug or compound.
Nope, there is an actual academic article, and this is a well-known process of doing transgenics on organisms to use them as a tool for synthesizing some drug or compound.
So this would be way more exciting if it wasn’t a tobacco plant. Seems like a damn good way to get someone addicted to everything all at once. I wonder how to addictive properties of nicotine...
So this would be way more exciting if it wasn’t a tobacco plant. Seems like a damn good way to get someone addicted to everything all at once. I wonder how to addictive properties of nicotine interact with the other stuff, none of which are habit forming like tobacco.
It is a little unfortunate they chose tobacco, but it looks like it's because it already has high levels of the substrate needed to synthesize the psychedelics. I'm not a chemist, so I could be...
It is a little unfortunate they chose tobacco, but it looks like it's because it already has high levels of the substrate needed to synthesize the psychedelics. I'm not a chemist, so I could be talking out my butt here, but I imagine there might be some ways to isolate the different compounds?
If it is economic enough, there’s probably a way to either separate the psychedelics OR suppress nicotine production. I wouldn’t be surprised if this becomes important if psychedelic compounds are...
If it is economic enough, there’s probably a way to either separate the psychedelics OR suppress nicotine production. I wouldn’t be surprised if this becomes important if psychedelic compounds are legalized/commercialized for pharmaceutical uses. It could also be useful for transitioning tobacco farmers away from smoking tobacco.
Food for thought: I don't really have anything insightful to add, but I'm imagining smoking a cigarette and getting your ego totally obliterated by the combination of DMT, psilocin, and bufotenine.
That might be one helluva way to get someone to quit smoking.
Or conversely, that's all they do from then on. Though could you imagine a pack a day of those? Oof.
After coming down from the most intense trip of your life, you forget where and when (and who?) you are. You find a pack of cigarettes in your pocket, and having the urge you light one up and take a drag...
...
I'm left to wonder, like for many things in life, what series of events leads people to learn something like the fact that the secretion from behind a toad's eye is hallucinogenic? ತ_ತ
Edit 38m: removed typos and repetitive passages
If you look at the folklore/mythos behind these things, its usually a case of an early human seeing an animal acting strange after ingesting a certain plant, like coffee or tobacco. In other cases, Caveman Fred eats a specific berry and dies, then his people create a story about how this type of bush or berry is cursed.
(At least that's what I remember from bits and pieces of research here and there.)
Going off what Queresote said, I'd be willing to bet that someone just ate a toad they caught at some point and had a really intense trip, and through trial and error they narrowed it down to the secretion coming from the eyes.
Is this not a April Fools thing?
Nope, there is an actual academic article, and this is a well-known process of doing transgenics on organisms to use them as a tool for synthesizing some drug or compound.
So this would be way more exciting if it wasn’t a tobacco plant. Seems like a damn good way to get someone addicted to everything all at once. I wonder how to addictive properties of nicotine interact with the other stuff, none of which are habit forming like tobacco.
It is a little unfortunate they chose tobacco, but it looks like it's because it already has high levels of the substrate needed to synthesize the psychedelics. I'm not a chemist, so I could be talking out my butt here, but I imagine there might be some ways to isolate the different compounds?
If it is economic enough, there’s probably a way to either separate the psychedelics OR suppress nicotine production. I wouldn’t be surprised if this becomes important if psychedelic compounds are legalized/commercialized for pharmaceutical uses. It could also be useful for transitioning tobacco farmers away from smoking tobacco.