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Too good to be true? A nonaddictive opioid without lethal side effects shows promise

Posted by spit-evil-olive-tips
Tags: medicine, pharmacology, opiates, clinical trials, opioids, side effects, drugs, addiction, pharmaceuticals, author.stephani sutherland, source.scientificamerican, paywall.soft
https://www.scientificamerican.com/article/too-good-to-be-true-a-nonaddictive-opioid-without-lethal-side-effects-shows-promise/

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Authors
Stephani Sutherland
Word count
874 words

1 comment

  1. Gaywallet
    Link
    Link to journal article An excerpt from the abstract:

    Link to journal article

    An excerpt from the abstract:

    AT-121 suppressed oxycodone’s reinforcing effects and exerted morphine-like analgesic effects in nonhuman primates. AT-121 treatment did not induce side effects commonly associated with opioids, such as respiratory depression, abuse potential, opioid-induced hyperalgesia, and physical dependence. Our results in nonhuman primates suggest that bifunctional NOP/MOP agonists with the appropriate balance of NOP and MOP agonist activity may provide a dual therapeutic action for safe and effective pain relief and treating prescription opioid abuse.

    4 votes