Cuspist's recent activity
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Comment on Very rare pathogenic genetic variants detected by SNP-chips are usually false positives: implications for direct-to-consumer genetic testing in ~science
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Very rare pathogenic genetic variants detected by SNP-chips are usually false positives: implications for direct-to-consumer genetic testing
8 votes -
Comment on Crypt Witch - Bad Trip Exorcism (2019) in ~music
Cuspist LinkInstrumental Stoner/Doom from Germany. For fans of Bongripper/Sleep/Electric Wizard etc.Instrumental Stoner/Doom from Germany. For fans of Bongripper/Sleep/Electric Wizard etc.
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Crypt Witch - Bad Trip Exorcism (2019)
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Comment on Mini painting in ~hobbies
Cuspist Link ParentYeah it's one of those things you just get a feel for through experience I think. It doesn't help that the amount of thinning required can vary between paints too. If in doubt, too much thinning...Yeah it's one of those things you just get a feel for through experience I think. It doesn't help that the amount of thinning required can vary between paints too. If in doubt, too much thinning is probably better than not enough, as you can always add more layers of paint.
If you haven't done so already, I'd highly recommend checking out the 'How to paint...' videos on the Warhammer TV YouTube channel. It only has GW models (obviously), but the techniques can be applied regardless of what you're painting. You'll soon be a novitiate of The Church of Two Thin Coats!
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Comment on Mini painting in ~hobbies
Cuspist LinkPainted a bunch when I was a kid, started up sporadically again over the last few years, mainly Games Workshop stuff. Your minis look good! If I could offer a tip, it looks like you might want to...Painted a bunch when I was a kid, started up sporadically again over the last few years, mainly Games Workshop stuff.
Your minis look good! If I could offer a tip, it looks like you might want to think out your paints a little (mix in a drop of water on a pallette, aim for skimmed-milk consistency), really helps the paint go on smooth and prevents it from clogging details on the model.
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Comment on It’s time to talk about ditching statistical significance in ~science
Cuspist LinkEditorial piece in Nature, with an accompanying letter with 800+ signatories adds to the growing number of scientists calling for an end to the misuse of P values and statistical significance to...Editorial piece in Nature, with an accompanying letter with 800+ signatories adds to the growing number of scientists calling for an end to the misuse of P values and statistical significance to 'prove' results.
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It’s time to talk about ditching statistical significance
19 votes -
Comment on Are there any scientists on Tildes? in ~science
Cuspist LinkMSc in genetics. Worked in various labs for the best part of a decade and now just starting my PhD alongside my current job as an RA in a leukemia research lab. Wish me luck!MSc in genetics. Worked in various labs for the best part of a decade and now just starting my PhD alongside my current job as an RA in a leukemia research lab. Wish me luck!
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Comment on Fundamentals of Data Visualisation in ~science
Cuspist LinkFree e-book from by Professor Claus Wilke. Written in R markdown, it covers the principles of designing clear and accurate figures do describe your data. Thought it may be useful for some people.Free e-book from by Professor Claus Wilke. Written in R markdown, it covers the principles of designing clear and accurate figures do describe your data. Thought it may be useful for some people.
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Fundamentals of Data Visualisation
3 votes -
Comment on It's the end of the gene as we know it in ~science
Cuspist LinkI'm not sure replacing the idea of genetic absolutism with one that is just as far to the other end of the spectrum is necessarily helpful.I'm not sure replacing the idea of genetic absolutism with one that is just as far to the other end of the spectrum is necessarily helpful.
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Comment on What have you been listening to this week? in ~music
Cuspist LinkCatching up with some releases from the last few months: Pig Destroyer - Head Cage Yob - Our Raw Heart Conan - Existential Void Guardian High on Fire - Electric Messiah And in non-metal news, Jon...Catching up with some releases from the last few months:
- Pig Destroyer - Head Cage
- Yob - Our Raw Heart
- Conan - Existential Void Guardian
- High on Fire - Electric Messiah
And in non-metal news, Jon Hopkins - Singularity is very enjoyable.
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Electrical stimulation allows paralysed patients to walk short distances
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Comment on Doctor Who S11E03 'Rosa' discussion thread in ~tv
Cuspist Link ParentSure, but that's rarely been the case in the modern era which is why this one sticks out for me, especially with how clearly all the 'lessons' were presented. I was half expecting the episode to...Sure, but that's rarely been the case in the modern era which is why this one sticks out for me, especially with how clearly all the 'lessons' were presented. I was half expecting the episode to pause and tell me to turn to page 75 in the textbook.
I don't have an issue with that, it was just very noticeably not in the modern Doctor Who style.
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Comment on Doctor Who S11E03 'Rosa' discussion thread in ~tv
Cuspist LinkMixed feelings about this one. I agree with @Algernon_Asimov that the episode was a bit too shoehorned together. It seemed like they wanted to tell the story of Rosa Parks first and foremost (it's...Mixed feelings about this one. I agree with @Algernon_Asimov that the episode was a bit too shoehorned together. It seemed like they wanted to tell the story of Rosa Parks first and foremost (it's currently Black History Month), then remembered it was still an episode of Doctor Who so added Generic Time Travelling Bad-Guy #24.
Ryan being overwhelmed by meeting MLK Jr. and cutting through his bluster was a nice moment that made me smile, and the full-on overt racism of the time was appropriately shocking in it's portrayal.
This certainly felt more like a history lesson than an episode of Doctor Who, and I think was aimed squarely at those not familiar with the history (i.e. kids), and one I'd happily show to mine as an entertaining way of learning about Rosa Parks.
Personally I like my Sci-Fi a little less on the nose, but this episode was never meant to appeal to that kind of viewer and that's fine. It's important history that everyone should learn about, and I don't mind so much that it's telling was given priority over making sure that the nominal villain had more motivation than just being a racist.
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Comment on The bad behavior of the richest: what I learned from wealth managers in ~life
Cuspist LinkBehaviors indulged in the rich are not just condemned in the poor, but used as a justification to punish them, denying them access to resources that keep them alive, such as healthcare and food assistance. Discussion of poverty has become almost impossible without moral outrage directed at lazy “welfare queens”, “crackheads” and other drug addicts, and the “promiscuous poor” (a phrase that has cropped up again and again in discussions of public benefits over more than a century).
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The bad behavior of the richest: what I learned from wealth managers
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Comment on <deleted topic> in ~tech
Cuspist (edited )LinkInteresting, but crying out for a comparison with crash type frequency of non-AVs. If rear-ending is of a similar frequency there, then it would suggest that it's the following driver rather than...Interesting, but crying out for a comparison with crash type frequency of non-AVs. If rear-ending is of a similar frequency there, then it would suggest that it's the following driver rather than the struck vehicle at fault. Or at least that the AVs are indeed behaving like human drivers.
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Comment on Doctor Who S11E02 'The Ghost Monument' discussion thread in ~tv
Cuspist Link ParentThat's probably what they were going for. Even so, you'd think the guy that can hologram himself halfway across the galaxy would be able afford a bodyguard or two (hundred). I think it was the...That's probably what they were going for. Even so, you'd think the guy that can hologram himself halfway across the galaxy would be able afford a bodyguard or two (hundred).
I think it was the instant reversal of his position after one sentence that made it seem so jarring to me. If they'd had a bit more negotiation about it, or even a "You and whose army?", "This one!" sort of thing, then it probably wouldn't have stuck out as much.
Still, a minor nitpick, I'm sure I've let much bigger plot holes slide by so I'm willing to give this one a pass.
The technology used in direct-to-consumer genetic testing performs very poorly in the detection of rare pathogenic variants, with postive predictive values for BRCA1 and 2 variants of only 4.2%.
Relevant article from The Guardian, discussing how this is problematic when consumers that may not fully understand the technical limitations see these variants in their raw data.