18 votes

How parents' trauma leaves biological traces in children

4 comments

  1. [3]
    RobotOverlord525
    Link
    At the end of the article, she talks about how this might be reversible through therapy. But with the recent "gene therapy" treatments I've read about, I wonder if that could be applied here...

    At the end of the article, she talks about how this might be reversible through therapy. But with the recent "gene therapy" treatments I've read about, I wonder if that could be applied here eventually, too.

    Summary of the article from Google Gemini.

    This article explores the long-term effects of trauma and its potential transmission across generations. Here are the key points:

    Trauma and Cortisol:

    • Exposure to trauma, such as the Holocaust or 9/11, can lead to post-traumatic stress disorder (PTSD) and low cortisol levels.
    • Cortisol is a stress hormone, and its low levels might indicate a dysregulation of the stress response system.

    Intergenerational Effects:

    • Studies suggest that trauma exposure in parents can influence their offspring even before birth.
    • This influence might occur through various pathways, including:
      • Epigenetic changes: Modifications to gene expression that don't alter the DNA code itself but can be passed down to future generations.
      • Changes in sperm and eggs: Trauma might affect the genetic material passed on to children.
      • Uterine environment: Trauma during pregnancy can alter the fetal environment, potentially impacting development.

    Examples:

    • Holocaust survivors: Their children were more likely to have low cortisol levels and anxiety disorders.
    • 9/11 babies: Those whose mothers were in their third trimester during the attacks had lower cortisol levels.

    Uncertainties and Future Research:

    • The full extent of intergenerational transmission of trauma is still under investigation.
    • The long-term consequences of these effects in offspring are not fully understood.
    • More research is needed to explore the mechanisms and potential interventions to mitigate the negative impacts.

    Overall, the article highlights the potential for trauma to have lasting effects not only on individuals but also on future generations. It emphasizes the need for further research to understand these complex mechanisms and develop strategies to support individuals and families affected by trauma.

    8 votes
    1. [2]
      nCeon
      Link Parent
      AFAIK gene therapy is typically aimed at changing the DNA code itself to change a protein. The heritable trauma is epigenetic, meaning (simplification ahead) it just changes "how much" or "when" a...

      AFAIK gene therapy is typically aimed at changing the DNA code itself to change a protein. The heritable trauma is epigenetic, meaning (simplification ahead) it just changes "how much" or "when" a protein is made.

      5 votes
      1. RobotOverlord525
        Link Parent
        Good point. Though I still wonder if there is an epigenetic analog to gene therapy. And whether it's easier or harder to implement, biotechnologically speaking.

        Good point.

        Though I still wonder if there is an epigenetic analog to gene therapy. And whether it's easier or harder to implement, biotechnologically speaking.