Interesting, I've looked at the instruction video and the protocole seems to be well designed. Following this principle all kind of open studies could be ran, although I doubt many people have the...
Interesting, I've looked at the instruction video and the protocole seems to be well designed. Following this principle all kind of open studies could be ran, although I doubt many people have the discipline to follow with the procedure.
In this case, I think the participants will be probably more disciplined than if one were to study other subjects, as people who microdose tend to be very meticulous about it, and are usually...
In this case, I think the participants will be probably more disciplined than if one were to study other subjects, as people who microdose tend to be very meticulous about it, and are usually passionate about the subject.
I think the biggest issue here will be the reliability of the doses. Those who do it with LSD won't really know how much they are taking, it will be a very rough estimate, and maybe it won't really be LSD but an structural analogue. That's problematic when you're dealing with doses in which a couple micrograms can make a difference. And for those who dose with mushrooms, the dose estimate will be even less reliable.
But I think overall this is a good first step, and the quality of the data will be way superior to anecdotal evidence.
Coincidentally, I stumbled on this video the other day, from the Dutch channel Drugslab (there are subtitles). The host tries microdosing LSD by dissolving a tab in demineralized water and dosing...
Coincidentally, I stumbled on this video the other day, from the Dutch channel Drugslab (there are subtitles). The host tries microdosing LSD by dissolving a tab in demineralized water and dosing volumetrically. The effects get stronger with each dose until she starts tripping, which someone in the comments suggested was probably because the LSD collects in the bottom of the bottle, especially if you don't shake it properly before use.
Dosing volumetrically is likely to be more accurate than just cutting tabs with scissors, though. There's no guarantee that the LSD is evenly spaced across the entire tab, but the drug readily dissolves in water.
Yes, the problem here is also that you don't know how accurate is the dosage per tab, because the manufacturer could have been sloppy with measurements or have an impure product, and LSD degrades...
Yes, the problem here is also that you don't know how accurate is the dosage per tab, because the manufacturer could have been sloppy with measurements or have an impure product, and LSD degrades over time, especially when improperly handled. Also, sellers tend to exaggerate, and it seems that most street acid that is sold as 100ug or 150ug is way less.
A somewhat better solution could be to use legal structural analogues such as ALD-52 or 1P-LSD. The latter is the LSD molecule with a propionyl radical which is thought to get detached in metabolism, leaving LSD on its place. As those are on a grey legal area, the labs producing them are legal, and at least the most reputable ones can be counted on being reliable with quantities and purity.
By the way, volumetric dosage is recommended, but you really need to use distilled water, which some people don't, and then get no effect but placebo.
Edit: on the Drugslab video: there's some speculation that, in some people, microdoses can cause a reverse tolerance so one actually becomes more sensitized to it. It's just speculation, but given that the mechanism of action of LSD is quite complex and it's poorly understood, who knows.
This study is being conducted by the Beckley Foundation and the Imperial College. It has some very clear limitations, but the authors hope it will shed some light on the effects of microdosis on...
This study is being conducted by the Beckley Foundation and the Imperial College. It has some very clear limitations, but the authors hope it will shed some light on the effects of microdosis on cognition. It is open to participation from home (they don't provide the microdoses).
Interesting, I've looked at the instruction video and the protocole seems to be well designed. Following this principle all kind of open studies could be ran, although I doubt many people have the discipline to follow with the procedure.
In this case, I think the participants will be probably more disciplined than if one were to study other subjects, as people who microdose tend to be very meticulous about it, and are usually passionate about the subject.
I think the biggest issue here will be the reliability of the doses. Those who do it with LSD won't really know how much they are taking, it will be a very rough estimate, and maybe it won't really be LSD but an structural analogue. That's problematic when you're dealing with doses in which a couple micrograms can make a difference. And for those who dose with mushrooms, the dose estimate will be even less reliable.
But I think overall this is a good first step, and the quality of the data will be way superior to anecdotal evidence.
Coincidentally, I stumbled on this video the other day, from the Dutch channel Drugslab (there are subtitles). The host tries microdosing LSD by dissolving a tab in demineralized water and dosing volumetrically. The effects get stronger with each dose until she starts tripping, which someone in the comments suggested was probably because the LSD collects in the bottom of the bottle, especially if you don't shake it properly before use.
Dosing volumetrically is likely to be more accurate than just cutting tabs with scissors, though. There's no guarantee that the LSD is evenly spaced across the entire tab, but the drug readily dissolves in water.
Yes, the problem here is also that you don't know how accurate is the dosage per tab, because the manufacturer could have been sloppy with measurements or have an impure product, and LSD degrades over time, especially when improperly handled. Also, sellers tend to exaggerate, and it seems that most street acid that is sold as 100ug or 150ug is way less.
A somewhat better solution could be to use legal structural analogues such as ALD-52 or 1P-LSD. The latter is the LSD molecule with a propionyl radical which is thought to get detached in metabolism, leaving LSD on its place. As those are on a grey legal area, the labs producing them are legal, and at least the most reputable ones can be counted on being reliable with quantities and purity.
By the way, volumetric dosage is recommended, but you really need to use distilled water, which some people don't, and then get no effect but placebo.
Edit: on the Drugslab video: there's some speculation that, in some people, microdoses can cause a reverse tolerance so one actually becomes more sensitized to it. It's just speculation, but given that the mechanism of action of LSD is quite complex and it's poorly understood, who knows.
Yeah, it would work better with a commercial product that everybody can have access to in the same way.
This study is being conducted by the Beckley Foundation and the Imperial College. It has some very clear limitations, but the authors hope it will shed some light on the effects of microdosis on cognition. It is open to participation from home (they don't provide the microdoses).