5 votes

How testosterone therapy is transforming aging

3 comments

  1. [3]
    Eric_the_Cerise
    Link
    Low-T has been a serious problem for me, for at least 15 years, but I have steadily avoided direct T-treatment, due to the various potentially horrible side-effects. While reading this, I...

    Low-T has been a serious problem for me, for at least 15 years, but I have steadily avoided direct T-treatment, due to the various potentially horrible side-effects. While reading this, I discovered a potential new (for me) treatment, enclomiphene. Now I am deep down the rabbit hole, investigating it ... so far, though, it sounds extremely promising.

    5 votes
    1. [2]
      Grimalkin
      Link Parent
      What have your investigations turned up so far? It looks like you can buy enclomiphene from multiple vendors.

      What have your investigations turned up so far? It looks like you can buy enclomiphene from multiple vendors.

      2 votes
      1. Eric_the_Cerise
        (edited )
        Link Parent
        It is not (yet?) approved by the FDA, for tech reasons, not specifically because it has proven dangerous. It has been tested and trialed a lot, so far with little indication of any serious risks...

        It is not (yet?) approved by the FDA, for tech reasons, not specifically because it has proven dangerous.

        It has been tested and trialed a lot, so far with little indication of any serious risks and only mild side-effects.

        It is a category of drug called a SERM, which selectively (the 'S'-part of SERM) blocks some estrogen receptors, causing the (male) body to naturally produce more T to compensate.

        Clomiphene is a much better-known and widely used drug, officially approved only for treating hormonal issues in women, but also widely used off-brand to treat low-T in men ... but it does have some significant side-effects. Enclomiphene is the half of clomiphene that does not cause those side-effects.

        The unofficial medical consensus seems to be that it is safe - particularly because it is part of clomiphene, which is already considered safe, and a (very!) effective treatment for low-T. But that's always tentative until there is more testing, and pending FDA approval.

        If you're the fearless bio-hacker type, it's absolutely worth considering.

        I've been suffering thru a half-lived life for 15+ years thanks to (probably) low-T. I'm going to talk my doctor into giving me a full baseline of bloodwork prior to trying it out on my own.

        ETA: I'm currently living in The Netherlands, where unfortunately, the healthcare system is actually surprisingly crappy, and additionally, the medical attitude here is that low-T is "normal" and I should just shut up and deal with it.

        ETA2: I personally believe that low-T in men is an as-yet undocumented global epidemic, caused by estrogen-mimicking pollutants in our environment (like micro-plastics), so a drug that selectively lowers male response to estrogen seems like a near-perfect solution (though not polluting the planet in the first place might have been a better plan).

        4 votes