28 votes

Oxford University vaccine is highly effective

7 comments

  1. [4]
    petrichor
    Link
    This is great news. The article posted to Hacker News (directly from Oxford) goes more in depth and takes perhaps a more skeptical view of the announcement. Also worth noting that the (speculated)...

    This is great news. The article posted to Hacker News (directly from Oxford) goes more in depth and takes perhaps a more skeptical view of the announcement. Also worth noting that the (speculated) prices mentioned here for Pfizer and Moderna's vaccines are per dose - being a two-dose treatment, they're really both around $30 to $50.

    My major takeaways from the article:

    • Currently, the vaccine is projected to be about 70% effective (taken from a somewhat-small amount of data) but could be has high as 90%
    • The company Oxford's collaborating with, AstraZeneca, has pledged to distribute the vaccine no-profit during the COVID pandemic (as opposed to Pfitzer and Moderna)
    • It costs around a tenth of the price of previously announced vaccines at $3-4 per dose (with a treatment consisting of two doses)
    • Oxford took a more "standard" approach to this vaccine, modifying a virus that causes the common cold and has been used in vaccines in the past
    • The vaccine needs to be kept at just a little above freezing - making it much, much easier to distribute and transport
    10 votes
    1. [3]
      MonkeyPants
      Link Parent
      Well now I am confused. The Sputnik V2 vaccine has a claimed 92% effectiveness with two full doses.

      62% effective if administered in two full doses.

      Well now I am confused. The Sputnik V2 vaccine has a claimed 92% effectiveness with two full doses.

      2 votes
      1. [2]
        petrichor
        Link Parent
        Although I'm having a remarkably difficult time finding information on the Sputnik V (V2?) vaccine, I strongly suspect that both of these claims are based off of rather small Phase III trials....

        Although I'm having a remarkably difficult time finding information on the Sputnik V (V2?) vaccine, I strongly suspect that both of these claims are based off of rather small Phase III trials.

        Also, even though they're both based off of the same general method of vaccination, they at the very least seem to be using different types of viruses, which, combined with noise, could account for the variation we're seeing here.

        5 votes
        1. aethicglass
          Link Parent
          Most likely also different testing methodology.

          Most likely also different testing methodology.

          3 votes
  2. Deimos
    Link
    Ars Technica has a good article that compares and contrasts the Oxford/AstraZeneca vaccine with what we know about the Pfizer and Moderna ones: AstraZeneca’s COVID-19 vaccine shows success: Here’s...

    Ars Technica has a good article that compares and contrasts the Oxford/AstraZeneca vaccine with what we know about the Pfizer and Moderna ones: AstraZeneca’s COVID-19 vaccine shows success: Here’s how it stacks up to others

    10 votes
  3. [2]
    MonkeyPants
    (edited )
    Link
    More fantastic news. I would have expected the Sputnik V2 vaccine (92% protection) and Oxford vaccine to have similar efficacy. Edit:

    More fantastic news.

    It can be stored at fridge temperature, which means it can be distributed to every corner of the world, unlike the Pfizer/BioNTech and Moderna vaccines, which need to be stored at much colder temperatures.

    The Oxford vaccine, at a price of around £3, also costs far less than Pfizer's (around £15) or Moderna's (£25) vaccines.

    Interim data suggests 70% protection

    I would have expected the Sputnik V2 vaccine (92% protection) and Oxford vaccine to have similar efficacy.

    the researchers say the figure may be as high as 90% by tweaking the dose.

    Edit:

    However, protection was 90% in an analysis of around 3,000 people on the trial who were given a half-sized first dose and a full-sized second dose.

    9 votes
    1. Pistos
      Link Parent
      And:

      And:

      AstraZeneca says it will make three billion doses for the world next year [and has] made a “no-profit pledge”

      12 votes