Has anyone tried it out? There's currently a preventative healthcare initiative going on in my country where they start screening people over 40 for chronic or potentially chronic conditions.

I went for my initial checkup with the doc today and, being juuuuust below morbid obesity with a BMI of 34, asked her about semaglutide as an adjunct to exercise controlling calorie intake. She's referring me to a weight loss clinic at my local public hospital where I can be assessed for suitability (If I'm not mistaken the clinic has hepatologists and endocrinologists on staff along with allied healthcare workers such as physios and nutritionists). This is great because it costs a bomb if I have to go private. The only wrinkle is that I'm oddly enough not diabetic or pre-diabetic so whether or not I'll qualify for socialised semaglutide is unclear but we live in hope.

I was wondering if any of you had tried any of the variants of semaglutide for obesity and what your experiences have been like.

by Wes Davis

A key cold medicine ingredient is basically worthless

The FDA’s 16-member advisory panel unanimously voted yesterday that oral phenylephrine, a common active ingredient in cold medications, is no better than a placebo for treating congestion.

Link to the article

The call by the panel sets up potential FDA action that could force the removal of certain over-the-counter medications containing the ingredient — including certain formulations of Mucinex, Sudafed, Tylenol, and NyQuil — from store shelves.
But FDA may hold off for many months, pending contested findings by drug makers and other considerations.

Data

Newer data from studies the panel says are more consistent with modern clinical trial standards showed phenylephrine simply “was not significantly different from placebo” in the recommended dosage, including trials from 2007 that the FDA had reviewed when considering the drug after a citizen petition prompted it to do so.

Bioavailability

The panel cited the drug’s low bioavailability, a term referring to qualities that allow the drug to be absorbed by the human body, as the main reason the drug should be removed from the market.

Jennifer Schwartzott said the drug “should have been removed from the market a long time ago,” while Dr. Stephen Clement said that although the drug itself isn’t dangerous, its usage by patients should be considered unsafe because it potentially delays actual treatment of disease symptoms.

Alternative

The panel cited pseudoephedrine as an effective alternative though while it’s technically available without a prescription, you must talk to a pharmacist to get it because, in large quantities, it can be used to make methamphetamines.

I've just started switching my medication and it's been pretty bad for me. Brain zaps are very frequent and I'm crying a lot. I'm struggling.

I've been trying to find out what other people's experience has been like when they switch meds. What is normal and what isn't. People who relate to brain zaps and how they deal with it. Are brain zaps even considered a real thing?

What has your experience been like?

So it is 80 degrees fahrenheit here today which usually would not be an issue for me but today I was too hot and sweaty. I am perimenopausal (49 years old) and I knew that could mess with heat tolerance. What I had not realized until today is that heat intolerance is also a side effect of many blood pressure medicines, antidepressants and allergy meds. And I am on all of those now.

I have just ordered some gadget that is a fan that goes around my neck and can be recharged via USB which seemed worth trying. And of course I will drink plenty of water, and try to stay in air conditioning whenever I can. Any other advice on how to deal with increased sensitivity to heat / higher heat intolerance? It is still early enough in the summer that the worst summer heat here is yet to come, so having some more tips might help me. Thanks!

Every person in my household takes a daily regimen of prescription medication and/or supplements. We keep ending up in situations where we run out of something because we don’t have a good way to keep track of our remaining supply of each thing. We need a better system for managing this!

We each use a 28-day (4 week) pill dispenser box which helps somewhat. I refill the dispensers when they are empty. The problem is, some of the medications run out in the last week of the dispenser. At the time I fill it, it’s way too early to call the pharmacy for a refill. But by the time the supply runs out I’ve forgotten about it and have to scramble to get more. I hope I’m explaining that clearly. It’s complicated because every medication runs out on a different schedule.

If you’ve got a solution to this problem please share it!