by Wes Davis

A key cold medicine ingredient is basically worthless

The FDA’s 16-member advisory panel unanimously voted yesterday that oral phenylephrine, a common active ingredient in cold medications, is no better than a placebo for treating congestion.

Link to the article

The call by the panel sets up potential FDA action that could force the removal of certain over-the-counter medications containing the ingredient — including certain formulations of Mucinex, Sudafed, Tylenol, and NyQuil — from store shelves.
But FDA may hold off for many months, pending contested findings by drug makers and other considerations.

Data

Newer data from studies the panel says are more consistent with modern clinical trial standards showed phenylephrine simply “was not significantly different from placebo” in the recommended dosage, including trials from 2007 that the FDA had reviewed when considering the drug after a citizen petition prompted it to do so.

Bioavailability

The panel cited the drug’s low bioavailability, a term referring to qualities that allow the drug to be absorbed by the human body, as the main reason the drug should be removed from the market.

Jennifer Schwartzott said the drug “should have been removed from the market a long time ago,” while Dr. Stephen Clement said that although the drug itself isn’t dangerous, its usage by patients should be considered unsafe because it potentially delays actual treatment of disease symptoms.

Alternative

The panel cited pseudoephedrine as an effective alternative though while it’s technically available without a prescription, you must talk to a pharmacist to get it because, in large quantities, it can be used to make methamphetamines.

I've just started switching my medication and it's been pretty bad for me. Brain zaps are very frequent and I'm crying a lot. I'm struggling.

I've been trying to find out what other people's experience has been like when they switch meds. What is normal and what isn't. People who relate to brain zaps and how they deal with it. Are brain zaps even considered a real thing?

What has your experience been like?

So it is 80 degrees fahrenheit here today which usually would not be an issue for me but today I was too hot and sweaty. I am perimenopausal (49 years old) and I knew that could mess with heat tolerance. What I had not realized until today is that heat intolerance is also a side effect of many blood pressure medicines, antidepressants and allergy meds. And I am on all of those now.

I have just ordered some gadget that is a fan that goes around my neck and can be recharged via USB which seemed worth trying. And of course I will drink plenty of water, and try to stay in air conditioning whenever I can. Any other advice on how to deal with increased sensitivity to heat / higher heat intolerance? It is still early enough in the summer that the worst summer heat here is yet to come, so having some more tips might help me. Thanks!

Every person in my household takes a daily regimen of prescription medication and/or supplements. We keep ending up in situations where we run out of something because we don’t have a good way to keep track of our remaining supply of each thing. We need a better system for managing this!

We each use a 28-day (4 week) pill dispenser box which helps somewhat. I refill the dispensers when they are empty. The problem is, some of the medications run out in the last week of the dispenser. At the time I fill it, it’s way too early to call the pharmacy for a refill. But by the time the supply runs out I’ve forgotten about it and have to scramble to get more. I hope I’m explaining that clearly. It’s complicated because every medication runs out on a different schedule.

If you’ve got a solution to this problem please share it!

I'll start this post off by summarizing my hair loss experience.

When I was 18, a few months shy of 19, I went to the barber and there was a miscommunication and the barber ended up buzzing my hair off. This is the first time that I was able to see my hairline in a while and I saw that it was higher than I remembered. I was scared at first, I couldn't believe that my hairline was receding. But then I read a few things figures maybe it was just maturing, and then I eventually forgot. Actually a few months later I was back thinking to whether I was losing my hair or not. I talked to a cousin of mine and he said something about a pill that he was taking but that it had a possible side effect of erectile dysfunction. I wasn't going to take a chance on that when I wasn't even sure if I was actually balding.

The next year and a half, I stop thinking about hair loss. It's like I had my memory wiped of that moment, probably due to stress from school. The only thing that happened is that I thought to myself was "man my hair is kind of weird right now." And also I had developed a scalp issue, which I later found out was psoriasis also due to stress.

So, right before the pandemic hits in February 2020, me and my dad go have lunch at this restaurant. I take a shower and go out. My hair is still wet by the time we go to the restaurant. My dad looks up at my hair and asks "are you losing your hair?" And that's when I realized that I was indeed going bald. For the next three months, I was going through all the stages of grief. I was wildly depressed and anxious. I did some research into possible treatments. It took me a while to learn (or re-learn) about the pill known as finasteride. I then find out about a website where you can buy prescription meds without a prescription shipped over from India so I buy finasteride from there and I started treatment on May 1st 2020. I was 20 years old. I then go to the dermatologist two months later and they prescribe me Dutasteride which I have been on ever since.

My initial side effect on the drug was watery semen, which cleared up a few weeks after starting the drug. My hair has re-grown a lot. It's back to it's original thickness, and my hairline has made a rather substantial comeback. It's not all back, but enough to the point where the average person wouldn't know I'm balding anymore.

Let me know if you have any questions. I would love to post pictures, but I rather not if that's okay with everyone.