Lazy userscript

It isn't hard to move (or recreate) the ignore button, you just need to add a bit of css to make it look the way you want. Web stuff isn't my wheelhouse, but here's an example of adding it to the footer:

    function moveIgnore() {
        let articles = Array.from(document.querySelectorAll("article"));
        for (let i = 1; i <= articles.length; i++) {
            let article = articles[i - 1];
            let footer = article.querySelectorAll("footer");
            //Add another column to the footer
            jQuery(footer).css("grid-template-columns", "1fr 1.5fr 0.7fr 1fr");
            let ignoreButton = article.querySelector('[data-ic-src$=ignore]');
            //Move button to the footer
            jQuery(ignoreButton).detach().appendTo(footer);
        }
    }

With the full script being:

// ==UserScript==
// @name         Tildes
// @namespace    http://tampermonkey.net/
// @version      0.1
// @description  Quickie convenience hotkeys for tildes.net
// @author       TT
// @match        *://tildes.net/*
// @icon         https://www.google.com/s2/favicons?sz=64&domain=tildes.net
// @grant        none
// @require      https://unpkg.com/hotkeys-js/dist/hotkeys.min.js
// ==/UserScript==
(function () {
    "use strict";
    let Action;
    (function (Action) {
        Action[Action["Invalid"] = 0] = "Invalid";
        Action[Action["Bookmark"] = 1] = "Bookmark";
        Action[Action["Comments"] = 2] = "Comments";
        Action[Action["Ignore"] = 3] = "Ignore";
        Action[Action["Open"] = 4] = "Open";
        Action[Action["Vote"] = 5] = "Vote";
    })(Action || (Action = {}));
    const regex = /tildes\.net(\/~(?<group>\w+))?/gi;
    let match = regex.exec(document.location);
    let defaultAction = Action.Ignore;
    //In a group if I wanted to support hotkeys there?
    if (match.groups.group) {
        //alert(match.groups.group);
    }
    else {
        addArticleNumbers();
        addMainHotkeys();
        moveIgnore();
    }
    //Route
    function routeAction(action, event, handler) {
        event.preventDefault();
        //Grab index.  Zero-index?
        let indexText = handler.key.substring(2);
        let index = parseInt(indexText) - 1;
        if (isNaN(index))
            return;
        actOnArticle(action, index);
    }
    function actOnArticle(action, index) {
        //Get article for index
        let article = document.querySelector(".topic-listing").children[index].children[0];
        //Do the thing
        switch (action) {
            case Action.Bookmark:
                if (article.style.borderStyle === "solid")
                    article.style.borderStyle = "none";
                else
                    article.style.borderStyle = "solid";
                article.querySelector('button[data-ic-put-to$="bookmark"]').click();
                break;
            case Action.Comments:
                article.querySelector(".topic-info-comments a").click();
                break;
            case Action.Ignore:
                //Hide vs blank?
                if (article.style.visibility === "hidden")
                    article.style.visibility = "visible";
                else
                    article.style.visibility = "hidden";
                // article.style.display = 'none';
                article.querySelector('button[data-ic-put-to$="ignore"]').click();
                break;
            case Action.Open:
                article.querySelector(".topic-title a").click();
                break;
            case Action.Vote:
                article.querySelector(".topic-voting").click();
                break;
        }
    }
    function addArticleNumbers() {
        let titles = Array.from(document.querySelectorAll(".topic-title a"));
        for (let i = 1; i <= titles.length; i++) {
            let title = titles[i - 1];
            title.text = i + " - " + title.text;
        }
    }
    function moveIgnore() {
        let articles = Array.from(document.querySelectorAll("article"));
        for (let i = 1; i <= articles.length; i++) {
            let article = articles[i - 1];
            let footer = article.querySelectorAll("footer");
            //Add another column to the footer
            jQuery(footer).css("grid-template-columns", "1fr 1.5fr 0.7fr 1fr");
            let ignoreButton = article.querySelector('[data-ic-src$=ignore]');
            //Move button to the footer
            jQuery(ignoreButton).detach().appendTo(footer);
        }
    }
    function addMainHotkeys() {
        //Set up handlers
        const handleBookmark = (event, handler) => routeAction(Action.Bookmark, event, handler);
        const handleComments = (event, handler) => routeAction(Action.Comments, event, handler);
        const handleIgnore = (event, handler) => routeAction(Action.Ignore, event, handler);
        const handleOpen = (event, handler) => routeAction(Action.Open, event, handler);
        const handleVote = (event, handler) => routeAction(Action.Vote, event, handler);
        hotkeys("b", (e, h) => (defaultAction = Action.Bookmark));
        hotkeys("c", (e, h) => (defaultAction = Action.Comments));
        hotkeys("i", (e, h) => (defaultAction = Action.Ignore));
        hotkeys("o", (e, h) => (defaultAction = Action.Open));
        hotkeys("v", (e, h) => (defaultAction = Action.Vote));
        hotkeys("shift+/", (e, h) => alert(getHelpText()));
        hotkeys("0+1", (e, h) => alert("foo"));
        hotkeys("1+0", (e, h) => alert("bar"));
        //Page nav
        hotkeys("left", (e, h) => Array.from(document.querySelectorAll(".pagination a"))
            .find((e) => e.textContent == "Prev")
            .click());
        hotkeys("right", (e, h) => Array.from(document.querySelectorAll(".pagination a"))
            .find((e) => e.textContent == "Next")
            .click());
        for (let i = 1; i <= 9; i++) {
            hotkeys("b+" + i, handleBookmark);
            hotkeys("c+" + i, handleComments);
            hotkeys("i+" + i, handleIgnore);
            hotkeys("o+" + i, handleOpen);
            hotkeys("v+" + i, handleVote);
            //Can't just use a number
            hotkeys("shift+" + i, (e, v) => {
                e.preventDefault();
                actOnArticle(defaultAction, i - 1);
            });
        }
    }
    function getHelpText() {
        return (`
    ←/→ = navigation 
    b = Bookmark, i = Ignore, v = Vote, 
    c = Open comments, o = Open link, 

    Action+[1-9] calls that action on the corresponding article

    Action by itself sets the (ephemeral) default mode which will be used on the article
    Shift+[1-9] calls the default action on the corresponding article

    Default = ` + defaultAction);
    }
    //https://stackoverflow.com/questions/123999/how-can-i-tell-if-a-dom-element-is-visible-in-the-current-viewport/7557433#7557433
    function inViewport(el) {
        var rect = el.getBoundingClientRect();
        return (rect.top >= 0 &&
            rect.left >= 0 &&
            rect.bottom <=
                (window.innerHeight || document.documentElement.clientHeight) &&
            rect.right <= (window.innerWidth || document.documentElement.clientWidth));
    }
})();

Unfortunately I have limited experience and access to Safari. It has a version of Tampermonkey supported, but with a $2 charge.

MeddleMonkey or Userscripts might work.

All the script is doing is injecting some javascript (https://unpkg.com/hotkeys-js/dist/hotkeys.min.js, and the code above) on tildes.net pages.