Ditto. I actually got the LYMERix vaccine in 2001-ish. I also got infected with Lyme in Germany a few years ago. Simple course of antibiotics treated it. Lyme seems to be a much bigger problem in...
Ditto. I actually got the LYMERix vaccine in 2001-ish. I also got infected with Lyme in Germany a few years ago. Simple course of antibiotics treated it. Lyme seems to be a much bigger problem in Germany (perhaps t/out the EU) than health providers seem to realize. Very often goes unreported here.
Yeah ticks and tick-borne diseases are increasingly becoming a problem in France as well. I haven't caught Lyme's but I spend a lot of time outdoors in the wild so it's only a matter of time... I...
Yeah ticks and tick-borne diseases are increasingly becoming a problem in France as well. I haven't caught Lyme's but I spend a lot of time outdoors in the wild so it's only a matter of time... I hope they don't assume it's not a problem in Europe and make access to the vaccine difficult.
I have little kids and have already pulled four ticks off of them this season. I lose sleep at night wondering if I messed up moving us out to the woods.
I have little kids and have already pulled four ticks off of them this season. I lose sleep at night wondering if I messed up moving us out to the woods.
I am excited for this and even tried to join the clinical trial but wasn't selected. With the increased prevalence of ticks in my area I hope that there will be efforts towards vaccines for some...
I am excited for this and even tried to join the clinical trial but wasn't selected. With the increased prevalence of ticks in my area I hope that there will be efforts towards vaccines for some of the other tick-borne diseases. Right now tick season is always slightly stressful, and while I would still be doing my daily tick checks, having some extra defense would be nice for peace of mind. Especially with how challenging finding nymphs is.
Four doses of an experimental vaccine to protect against Lyme disease reduced the number of tick-borne infections by more than 70 percent, according to Pfizer and Valneva, the pharmaceutical companies developing the shot.
[...]
Pfizer said in a statement the companies are “confident in the vaccine’s potential” and plan to submit the data to regulatory authorities seeking approval. If successful, it could become the only Lyme disease vaccine available for people — although it would not be the first.
A previous Lyme disease vaccine, called LYMErix, was approved in 1998. But it became controversial because of reports of adverse events following vaccination, and it was pulled from the market four years later due to poor sales.
[...]
The results of the trial, which tested the vaccine against a placebo in 9,400 people ages 5 and up, have not yet been published or peer reviewed. Pfizer said in its statement that its late-stage clinical trial just missed a statistical cutoff for success, because there were fewer than expected cases of Lyme disease in the trial.
A Lyme disease vaccine would be wonderful, and perhaps wider knowledge of the disease and its implications now might make it more popular. But I do have to wonder a bit at this article's tone, as...
A Lyme disease vaccine would be wonderful, and perhaps wider knowledge of the disease and its implications now might make it more popular.
But I do have to wonder a bit at this article's tone, as the implication seems to be that the clinical trial failed?
Edit:
Yes, looking into this more, this is not the news the Washington Post is reporting it as being. Even Pfizer's own press release is clearer about the failure, and this article points out that the announcement brought a ~40% crash in the associated smaller company's stock. That 73% efficacy headline comes with a 95% confidence interval that goes down to 16%. The second pre-registered analysis did succeed, but with a lower bound of 22%.
Yes, it's likely that was a problem with the incidence of the disease in the study, but the study is done. Pfizer's statement is that they plan to submit it for approval in the US and EU despite the first analysis failure. Given the current state of US regulators, I would worry about the chances for a vaccine with good results; the EU is perhaps a better prospect, though on the other hand, being in areas with ticks in both the US and the EU, the disease seems to be taken much more seriously in the US.
So it sounds like the evidence isn’t good enough to say it’s proven, but so far it seems promising?
The results of the trial, which tested the vaccine against a placebo in 9,400 people ages 5 and up, have not yet been published or peer reviewed. Pfizer said in its statement that its late-stage clinical trial just missed a statistical cutoff for success, because there were fewer than expected cases of Lyme disease in the trial.
So it sounds like the evidence isn’t good enough to say it’s proven, but so far it seems promising?
This doesn't appear to be a matter of 'so far': it appears the announcement was of the study being finished. Pfizer is just going to try to submit it for approval with these results.
This doesn't appear to be a matter of 'so far': it appears the announcement was of the study being finished. Pfizer is just going to try to submit it for approval with these results.
When this becomes available I swear I'll be first in line to get it. Really hoping it becomes available soon!
Ditto. I actually got the LYMERix vaccine in 2001-ish. I also got infected with Lyme in Germany a few years ago. Simple course of antibiotics treated it. Lyme seems to be a much bigger problem in Germany (perhaps t/out the EU) than health providers seem to realize. Very often goes unreported here.
Yeah ticks and tick-borne diseases are increasingly becoming a problem in France as well. I haven't caught Lyme's but I spend a lot of time outdoors in the wild so it's only a matter of time... I hope they don't assume it's not a problem in Europe and make access to the vaccine difficult.
I have little kids and have already pulled four ticks off of them this season. I lose sleep at night wondering if I messed up moving us out to the woods.
I am excited for this and even tried to join the clinical trial but wasn't selected. With the increased prevalence of ticks in my area I hope that there will be efforts towards vaccines for some of the other tick-borne diseases. Right now tick season is always slightly stressful, and while I would still be doing my daily tick checks, having some extra defense would be nice for peace of mind. Especially with how challenging finding nymphs is.
From the article:
[...]
[...]
A Lyme disease vaccine would be wonderful, and perhaps wider knowledge of the disease and its implications now might make it more popular.
But I do have to wonder a bit at this article's tone, as the implication seems to be that the clinical trial failed?
Edit:
Yes, looking into this more, this is not the news the Washington Post is reporting it as being. Even Pfizer's own press release is clearer about the failure, and this article points out that the announcement brought a ~40% crash in the associated smaller company's stock. That 73% efficacy headline comes with a 95% confidence interval that goes down to 16%. The second pre-registered analysis did succeed, but with a lower bound of 22%.
Yes, it's likely that was a problem with the incidence of the disease in the study, but the study is done. Pfizer's statement is that they plan to submit it for approval in the US and EU despite the first analysis failure. Given the current state of US regulators, I would worry about the chances for a vaccine with good results; the EU is perhaps a better prospect, though on the other hand, being in areas with ticks in both the US and the EU, the disease seems to be taken much more seriously in the US.
So it sounds like the evidence isn’t good enough to say it’s proven, but so far it seems promising?
This doesn't appear to be a matter of 'so far': it appears the announcement was of the study being finished. Pfizer is just going to try to submit it for approval with these results.
I meant that more in a general sense of "we'll see what actually happens."