(I don't personally have any interest in trying much of anything if anyone interprets this post as such. And yes, 'drugs' is a general/vague and loaded term and I might be asking too much in a single topic)

My opinion on drug legalization was generally summed up as pro-legalization, but really because just banning everything doesn't work and generally just understood drugs as bad.

However, I often hear people talking about drugs as giving them new experiences, enhancing sensations and generally being fun.

However, being Brazilian/Latin American, drugs here are often associated with illegal traffic, gangs, poverty, crime, among other bad things and, unlike in the US and Europe, this is generally something that is exterior to us, nor a position held overwhelmingly by social conservatives who rant about "the devil's lettuce", because it affects poor people (although, yes, that's also true in the US).

So back to the title question:

What separates people that have positive and negative experiences with drugs?

The 3 obvious differences are:

The drugs used. Drug gangs traffic stuff like cocaine and areas like [the] Cracolândia are populated by people dependent on crack, while people advocate for legalization of weed or psychedelics which are very different and "weed is no worse than alcohol" is confirmed to be truth and has been for a while. A question I have concerning this is what separates 'good' drugs from 'bad' drugs?

Preparation, since obviously you don't want to be high at work (or asking for help on a Tildes thread, that happened.) A question I have in that area is what preparations do people take before taking weed or DMT and other drugs.

Their motivations for taking drugs, since a lot of the bad examples come from people taking drugs to fill holes in their lives, while good examples are the vast majority of the time recreational (aka, for fun.)

Are there any other differences anyone wants to delineate?

I lost my father to it, we're struggling to get my mom to quit who survived a heart attack some 15 years ago, just had a thyroidectomy, and is recently diagnosed level 2 COPD. I have never smoked in my life, and I hate the thing with a passion. But I also wonder that is it that makes people smoke, especially tobacco products like cigarettes, despite the slew of horrible things it does to your body. To this day I've been asking people this question, and because Turkey is big on smoking, there is no shortage of people to ask, and it's been only once that I got a positive answer regarding the experience: one particular college-goer told me that it was "tasty". Apart from that, from what I've heard to date, I've collected that all that cigarettes do to you is to give you a fix of nicotine, and the rest is practically slow suicide (and homicide if anybody's present about you while you smoke).

So, help me please: tell me why you smoke. This is one of the biggest curiosities of mine to this day.