Tannhauser's recent activity

  1. Comment on How do people get over enshittification? in ~life

    Tannhauser
    Link Parent
    Gustin is the brand I wear for jeans, and they're real solid. One can find them rather cheap secondhand, too.

    Gustin is the brand I wear for jeans, and they're real solid. One can find them rather cheap secondhand, too.

    2 votes

  2. Comment on Any recommendations for books, novellas and short story collections? in ~books

    Tannhauser
    Link
    Sum by David Eagleman is a collection of ~40 short stories about the afterlife. I thought it to be interesting.

    Sum by David Eagleman is a collection of ~40 short stories about the afterlife. I thought it to be interesting.

  3. Comment on Weekly Middle East war megathread - week of October 14 in ~news

    Tannhauser
    Link Parent
    In an ideal world, this would be a great offramp for the Gaza operation.

    In an ideal world, this would be a great offramp for the Gaza operation.

    6 votes

  4. Comment on The elite college students who can’t read books in ~humanities

    Tannhauser
    Link Parent
    Oh my, that sounds like a mess of a curriculum.

    Oh my, that sounds like a mess of a curriculum.

    3 votes

  5. Comment on The elite college students who can’t read books in ~humanities

    Tannhauser
    Link Parent
    As someone who went to a good American public school and only has some familiarity with the Cambridge system, could you expand on why you think the US AP system outperforms it?

    As someone who went to a good American public school and only has some familiarity with the Cambridge system, could you expand on why you think the US AP system outperforms it?

    7 votes

  6. Comment on Russia-Ukraine War megathread - September 2024 in ~news

    Tannhauser
    Link Parent
    Also, for the New Yorker, clearing cookies has always worked for me.

    Also, for the New Yorker, clearing cookies has always worked for me.

    4 votes

  7. Comment on Data finds US Republican areas search more frequently for transgender porn in ~society

    Tannhauser
    Link Parent
    I will also say on the other side, there are definitely a sizeable fraction of people who advertise/portray/bill themselves as femboys while also being trans.

    I will also say on the other side, there are definitely a sizeable fraction of people who advertise/portray/bill themselves as femboys while also being trans.

    9 votes

  8. Comment on Academic publishers face class action over ‘peer review’ pay, other restrictions in ~science

    Tannhauser
    Link Parent
    The good publishers will also (in theory) vet papers for scientific quality (and often novelty) through editorial review and peer review. There is a clear difference in general quality from a...

    The good publishers will also (in theory) vet papers for scientific quality (and often novelty) through editorial review and peer review. There is a clear difference in general quality from a paper published in a Cell Press journal compared to an MDPI journal, for instance.

    This is not me endorsing the publishers' general practices, however.

    15 votes

  9. Comment on Weekly US politics news and updates thread - week of September 9 in ~society

  11. Comment on What is your opinion on Dan Brown novels? in ~books

  12. Comment on Positive (personal) news discussion? in ~talk

    Tannhauser
    Link Parent
    Ahh, you had more medical responsibilities prior. I assumed you were just research based PhD.

    Ahh, you had more medical responsibilities prior. I assumed you were just research based PhD.

    1 vote

  13. Comment on Positive (personal) news discussion? in ~talk

    Tannhauser
    Link Parent
    Congrats! By clinical title series to regular do you mean like going from Asst. Prof. in Pathology to the XXX Assoc. Prof. in Neuroscience?

    Congrats!

    By clinical title series to regular do you mean like going from Asst. Prof. in Pathology to the XXX Assoc. Prof. in Neuroscience?

    1 vote

  14. Comment on Canadian pet DNA company sends back dog breed results from human sample a second time in ~life.pets

    Tannhauser
    Link Parent
    I suspect DNA microarrays (for SNP/allele profiling) would be used to get the most traits identified at a reasonable cost.

    I suspect DNA microarrays (for SNP/allele profiling) would be used to get the most traits identified at a reasonable cost.

    4 votes

  15. Comment on Canadian father asks court to stop 27-year-old daughter's MAID death, review doctors' sign-off in ~health

    Tannhauser
    Link Parent
    As a non-Canadian who understands the broad strokes of MAiD but not the whole path to its approval, was there ever discussion around having specific panels of doctors to make the MAiD decisions...

    As a non-Canadian who understands the broad strokes of MAiD but not the whole path to its approval, was there ever discussion around having specific panels of doctors to make the MAiD decisions rather than it seemingly be something where one could "doctor shop" to find some that will sign off?

    4 votes

  16. Comment on Unique things to do in Las Vegas? (and Los Angeles) in ~travel

    Tannhauser
    Link Parent
    I went to the Meow Wolf installation in New Mexico (House of Eternal Return, iirc), and I would 100% recommend doing this if it's anywhere close to as good.

    I went to the Meow Wolf installation in New Mexico (House of Eternal Return, iirc), and I would 100% recommend doing this if it's anywhere close to as good.

    5 votes

  17. Comment on German man deliberately receives 217 Covid vaccinations over twenty-nine months, with no adverse events or strong effect on immune system in ~science

    Tannhauser
    Link Parent
    No, I am saying that taking the Dengue vaccine without prior infection makes you more susceptible to severe infection. As N (vaccines) goes from 0 --> 1, the quality of the immune response goes...

    No, I am saying that taking the Dengue vaccine without prior infection makes you more susceptible to severe infection. As N (vaccines) goes from 0 --> 1, the quality of the immune response goes down. In the linked meta analysis I sent in my first comment, it states that for influenza vaccinations, having 1 > 2 > 0, showing that increased vaccinations can, in fact, decrease ones immunity.

    From the start of the paper discussed in the linked article:

    Prime-boost vaccinations can enhance immune responses,(1) whereas chronic antigen exposure can cause immune tolerance.(2) In humans, the benefits, limitations, and risks of repetitive vaccination remain poorly understood.

    The study is interesting because there wasn't much of a change in immunity in either direction going from a standard dosing regimen to 217 vaccinations.

    Addressing your final paragraph: Getting repeated exposures to the same antigen can also enhance your immunity, hence getting a series of 2 COVID-19 vaccinations initially (at least for the Moderna and Pfizer vaccines).

    10 votes

  18. Comment on German man deliberately receives 217 Covid vaccinations over twenty-nine months, with no adverse events or strong effect on immune system in ~science

    Tannhauser
    Link Parent
    Yes, vaccination is recommended if you've had a prior dengue infection, but if you've never had that first infection, you run the risk of the overreaction on your first infection if you have been...

    Yes, vaccination is recommended if you've had a prior dengue infection, but if you've never had that first infection, you run the risk of the overreaction on your first infection if you have been vaccinated.

    https://www.cdc.gov/dengue/vaccine/hcp/eligibility/index.html

    3 votes

  19. Comment on German man deliberately receives 217 Covid vaccinations over twenty-nine months, with no adverse events or strong effect on immune system in ~science

    Tannhauser
    Link Parent
    It's not that the Dengue vaccine causes side effects, but instead alters the immune response. The vaccine itself has no side effects, but will cause a future infection to be worse. The man not...

    It's not that the Dengue vaccine causes side effects, but instead alters the immune response. The vaccine itself has no side effects, but will cause a future infection to be worse. The man not being directly affected by repetitive vaccinations would be expected, but no qualitative changes in his anti-SARS-CoV-2 immunity is interesting (and probably why this got published in The Lancet Infectious Disease, which is a top tier ID journal).

    17 votes

  20. Comment on German man deliberately receives 217 Covid vaccinations over twenty-nine months, with no adverse events or strong effect on immune system in ~science

    Tannhauser
    Link Parent
    I'd disagree that this was a very expected outcome. Immunological memory is often very complicated and nonintuitive. For instance, the current FDA approved Dengue vaccine is only recommended if...

    I'd disagree that this was a very expected outcome. Immunological memory is often very complicated and nonintuitive. For instance, the current FDA approved Dengue vaccine is only recommended if you're already seropositive as getting it prior to infection increases risk of a severe infection. In contrast, Takeda is trialing a new vaccine against Dengue that is currently appearing to be fine to give to both seropositive and seronegative people. There's also lots of literature and meta reviews on repeated influenza vaccinations being detrimental (though still better than being unvaccinated).

    23 votes