Tannhauser's recent activity

  1. Comment on Positive (personal) news discussion? in ~talk

    Tannhauser
    Link Parent
    Ahh, you had more medical responsibilities prior. I assumed you were just research based PhD.

    Ahh, you had more medical responsibilities prior. I assumed you were just research based PhD.

    1 vote

  2. Comment on Positive (personal) news discussion? in ~talk

    Tannhauser
    Link Parent
    Congrats! By clinical title series to regular do you mean like going from Asst. Prof. in Pathology to the XXX Assoc. Prof. in Neuroscience?

    Congrats!

    By clinical title series to regular do you mean like going from Asst. Prof. in Pathology to the XXX Assoc. Prof. in Neuroscience?

    1 vote

  3. Comment on Canadian pet DNA company sends back dog breed results from human sample a second time in ~life.pets

    Tannhauser
    Link Parent
    I suspect DNA microarrays (for SNP/allele profiling) would be used to get the most traits identified at a reasonable cost.

    I suspect DNA microarrays (for SNP/allele profiling) would be used to get the most traits identified at a reasonable cost.

    4 votes

  4. Comment on Canadian father asks court to stop 27-year-old daughter's MAID death, review doctors' sign-off in ~health

    Tannhauser
    Link Parent
    As a non-Canadian who understands the broad strokes of MAiD but not the whole path to its approval, was there ever discussion around having specific panels of doctors to make the MAiD decisions...

    As a non-Canadian who understands the broad strokes of MAiD but not the whole path to its approval, was there ever discussion around having specific panels of doctors to make the MAiD decisions rather than it seemingly be something where one could "doctor shop" to find some that will sign off?

    4 votes

  5. Comment on Unique things to do in Las Vegas? (and Los Angeles) in ~travel

    Tannhauser
    Link Parent
    I went to the Meow Wolf installation in New Mexico (House of Eternal Return, iirc), and I would 100% recommend doing this if it's anywhere close to as good.

    I went to the Meow Wolf installation in New Mexico (House of Eternal Return, iirc), and I would 100% recommend doing this if it's anywhere close to as good.

    5 votes

  6. Comment on German man deliberately receives 217 Covid vaccinations over twenty-nine months, with no adverse events or strong effect on immune system in ~science

    Tannhauser
    Link Parent
    No, I am saying that taking the Dengue vaccine without prior infection makes you more susceptible to severe infection. As N (vaccines) goes from 0 --> 1, the quality of the immune response goes...

    No, I am saying that taking the Dengue vaccine without prior infection makes you more susceptible to severe infection. As N (vaccines) goes from 0 --> 1, the quality of the immune response goes down. In the linked meta analysis I sent in my first comment, it states that for influenza vaccinations, having 1 > 2 > 0, showing that increased vaccinations can, in fact, decrease ones immunity.

    From the start of the paper discussed in the linked article:

    Prime-boost vaccinations can enhance immune responses,(1) whereas chronic antigen exposure can cause immune tolerance.(2) In humans, the benefits, limitations, and risks of repetitive vaccination remain poorly understood.

    The study is interesting because there wasn't much of a change in immunity in either direction going from a standard dosing regimen to 217 vaccinations.

    Addressing your final paragraph: Getting repeated exposures to the same antigen can also enhance your immunity, hence getting a series of 2 COVID-19 vaccinations initially (at least for the Moderna and Pfizer vaccines).

    10 votes

  7. Comment on German man deliberately receives 217 Covid vaccinations over twenty-nine months, with no adverse events or strong effect on immune system in ~science

    Tannhauser
    Link Parent
    Yes, vaccination is recommended if you've had a prior dengue infection, but if you've never had that first infection, you run the risk of the overreaction on your first infection if you have been...

    Yes, vaccination is recommended if you've had a prior dengue infection, but if you've never had that first infection, you run the risk of the overreaction on your first infection if you have been vaccinated.

    https://www.cdc.gov/dengue/vaccine/hcp/eligibility/index.html

    3 votes

  8. Comment on German man deliberately receives 217 Covid vaccinations over twenty-nine months, with no adverse events or strong effect on immune system in ~science

    Tannhauser
    Link Parent
    It's not that the Dengue vaccine causes side effects, but instead alters the immune response. The vaccine itself has no side effects, but will cause a future infection to be worse. The man not...

    It's not that the Dengue vaccine causes side effects, but instead alters the immune response. The vaccine itself has no side effects, but will cause a future infection to be worse. The man not being directly affected by repetitive vaccinations would be expected, but no qualitative changes in his anti-SARS-CoV-2 immunity is interesting (and probably why this got published in The Lancet Infectious Disease, which is a top tier ID journal).

    17 votes

  9. Comment on German man deliberately receives 217 Covid vaccinations over twenty-nine months, with no adverse events or strong effect on immune system in ~science

    Tannhauser
    Link Parent
    I'd disagree that this was a very expected outcome. Immunological memory is often very complicated and nonintuitive. For instance, the current FDA approved Dengue vaccine is only recommended if...

    I'd disagree that this was a very expected outcome. Immunological memory is often very complicated and nonintuitive. For instance, the current FDA approved Dengue vaccine is only recommended if you're already seropositive as getting it prior to infection increases risk of a severe infection. In contrast, Takeda is trialing a new vaccine against Dengue that is currently appearing to be fine to give to both seropositive and seronegative people. There's also lots of literature and meta reviews on repeated influenza vaccinations being detrimental (though still better than being unvaccinated).

    23 votes

  10. Comment on Are there any watch enthusiasts on Tildes who could help me out with a few questions? in ~hobbies

    Tannhauser
    Link
    If this model is on waitlist at Rolex boutiques and authorized sellers, a greymarket dealer may have new watches available at a premium.

    If this model is on waitlist at Rolex boutiques and authorized sellers, a greymarket dealer may have new watches available at a premium.

    2 votes

  11. Comment on Squishmallows vs. Build-A-Bear, the cutest legal scuffle ever, is heating up in ~finance

    Tannhauser
    Link Parent
    Axolotls can be white/pink naturally, so I think it's very reasonable that companies would have the same general color schemes for a cute axolotl (I feel like far fewer people would want a brown one).

    Axolotls can be white/pink naturally, so I think it's very reasonable that companies would have the same general color schemes for a cute axolotl (I feel like far fewer people would want a brown one).

    6 votes

  12. Comment on What would America look like if it lost WWIII? in ~misc

    Tannhauser
    Link Parent
    Your comment reminded me about Yale's Existential Threats Initiative, which I learned about from this Atlantic article. Relevant paragraphs:

    Your comment reminded me about Yale's Existential Threats Initiative, which I learned about from this Atlantic article.

    Relevant paragraphs:

    Yale’s competitive-admission clubs include many that are notoriously exclusive but also more surprising entries, such as the community-service club. One of Zhang’s rejections came from the Existential Threats Initiative, which meets to discuss issues such as climate change and AI. Zhang was turned away for not having enough experience dealing with existential threats. Her rejection email encouraged her to listen to more podcasts, such as 80,000 Hours (tagline: “In-depth conversations about the world’s most pressing problems”) or otherwise gain expertise in the field.

    Ben Snyder, a recent Yale grad who co-founded Existential Threats in 2022, told me the club is simply not for beginners.
    “We wanted to be more selective so we could have more advanced conversations,” said Snyder, whose expertise in this subject includes having researched the risk potential of pandemics at the Stanford Center for International Security and Cooperation last summer.

    7 votes

  13. Comment on Study reveals why women are at greater risk of autoimmune disease: A molecule made by one X chromosome in every female cell can generate antibodies to a woman’s own tissues in ~health

  14. Comment on Scientists document first-ever transmitted Alzheimer’s cases, tied to no-longer-used medical procedure in ~health

  15. Comment on Scientists document first-ever transmitted Alzheimer’s cases, tied to no-longer-used medical procedure in ~health

  16. Comment on "If the role of dysfunctional parenting in psychological disorders was ever fully recognized, the DSM would shrink to the size of a thin pamphlet" in ~health.mental

    Tannhauser
    Link Parent
    A very simple way one can determine effects of genetics vs parenting is looking at rates of concurrence in identical twins vs. fraternal twins. The former is 100% genetically the same while the...

    A very simple way one can determine effects of genetics vs parenting is looking at rates of concurrence in identical twins vs. fraternal twins. The former is 100% genetically the same while the latter are 50% however both will be raised in similar environments.

    12 votes

  17. Comment on How much does a creator's worldview influence whether you use their tech or consume their media? in ~talk

    Tannhauser
    Link Parent
    What about someone like Brandon Sanderson? As far as I know he personally doesn't hold terrible views, but he does donate large sums of money to the Mormon church.

    What about someone like Brandon Sanderson? As far as I know he personally doesn't hold terrible views, but he does donate large sums of money to the Mormon church.

    4 votes

  18. Comment on Traveling to Italy in February for ten days, what to know? in ~travel

    Tannhauser
    Link Parent
    When I visited Spain last year, I got an anti-pickpocket crossbody bag. It has steel cables running through the strap so it cannot easily be cut off, and the zippers lock shut so one cannot...

    When I visited Spain last year, I got an anti-pickpocket crossbody bag. It has steel cables running through the strap so it cannot easily be cut off, and the zippers lock shut so one cannot surreptitiously open the bag and take your belongings.

    2 votes

  19. Comment on Venezuelan referendum approves takeover of oil-rich region of Guyana in ~news

    Tannhauser
    Link Parent
    Given it's over oil, that could lead to other nations taking sides.

    Given it's over oil, that could lead to other nations taking sides.

    9 votes

  20. Comment on Can someone please recommend me a no BS printer I can use like half a dozen times a year in ~tech

    Tannhauser
    Link Parent
    If you can put it on a company card, I will echo the recommendations for a good quality laser printer.

    If you can put it on a company card, I will echo the recommendations for a good quality laser printer.

    9 votes