Aging is a complex process associated with nearly all diseases. Understanding the molecular changes underlying aging and identifying therapeutic targets for aging-related diseases are crucial for increasing healthspan. Although many studies have explored linear changes during aging, the prevalence of aging-related diseases and mortality risk accelerates after specific time points, indicating the importance of studying nonlinear molecular changes. In this study, we performed comprehensive multi-omics profiling on a longitudinal human cohort of 108 participants, aged between 25 years and 75 years. The participants resided in California, United States, and were tracked for a median period of 1.7 years, with a maximum follow-up duration of 6.8 years. The analysis revealed consistent nonlinear patterns in molecular markers of aging, with substantial dysregulation occurring at two major periods occurring at approximately 44 years and 60 years of chronological age. Distinct molecules and functional pathways associated with these periods were also identified, such as immune regulation and carbohydrate metabolism that shifted during the 60-year transition and cardiovascular disease, lipid and alcohol metabolism changes at the 40-year transition. Overall, this research demonstrates that functions and risks of aging-related diseases change nonlinearly across the human lifespan and provides insights into the molecular and biological pathways involved in these changes.
I dunno if there’s any control on physical fitness. Certainly the current younger crowd are much more health conscious than before, and things like regular weightlifting mitigate all sorts of age...
I dunno if there’s any control on physical fitness.
Certainly the current younger crowd are much more health conscious than before, and things like regular weightlifting mitigate all sorts of age related things.
For example women who don’t weight train can lose bone density quickly in older age, but many more women are now weight lifting to mitigate it.
Its hard to believe that the new lifestyle factors and nutrition knowledge of the current crop of 20-40 year olds isn't markedly different than the current 44-60 year olds, and I am optimistic that any aging cliff around 44 can be fought off with weight lifting and protein rich diets.
I don't know about 'enough' but it is certainly better than nothing. And running does increase bone density as well. I think the best thing for the body may be everything in moderation. That said,...
I don't know about 'enough' but it is certainly better than nothing. And running does increase bone density as well. I think the best thing for the body may be everything in moderation. That said, as someone who has done periods of both cardio and weight training, the base line of weight training is so much easier than cardio that it is insane. My experience is specifically with programs like Starting Strength and Stronglifts, but doing 5 sets of 5 squats with a barbell is so much easier than running a mile. If you can't manage it, then you're just starting with too much weight.
The way strength incrase works is actually by recruiting additional mitochondria into each muscle cell. This is a process that takes time. My understanding is that once they are there, the structure stays there. So increasing your baseline mitochondria per cell at a younger age is much, much easier. This is likely going to translate to increase longevity.
For good health in age, muscles are paramount: being able to carry stuff, having the leg strength to keep balance, having the core muscles not to gradually hunch more and more forwards, having...
For good health in age, muscles are paramount: being able to carry stuff, having the leg strength to keep balance, having the core muscles not to gradually hunch more and more forwards, having muscles to lose if I become sick for a period, avoiding breaking things by landing on muscles or having the strength to dampen a fall.
You get the idea. Strength training is extremely important.
I used to bike up hills/mountains 6 days per week during the pandemic. But at some point I threw a frisbee and almost injured my T-rex arms just from flicking my elbow wrong. I realized that...
I used to bike up hills/mountains 6 days per week during the pandemic. But at some point I threw a frisbee and almost injured my T-rex arms just from flicking my elbow wrong. I realized that having a really strong heart, legs, and lungs isn't covering all of my bases. Sure, I'm not likely to have a heart attack or heart disease as I age on that routine. But I also don't want to lose mobility in an arm because of something stupid.
Muscle is the currency of health. Think of it like a battery, where you want as much muscle mass as you can get while entering old age -- since it's harder to put on and maintain then due to an...
Muscle is the currency of health. Think of it like a battery, where you want as much muscle mass as you can get while entering old age -- since it's harder to put on and maintain then due to an increasingly shitty deamination process, so you'll have to eat more total overall protein as well compared to when you were twenty years old.
You want this muscle to prevent falls, which are essentially a death sentence/crippling past a certain age. Of the controllable variables, I'd say physical health is 45% diet (maintaining ideal body mass for your sex, height, age, and frame size with about a gram of protein per pound of lean body mass and whatever calories you require to do the stuff you wanna do), 25% cardio, 25% resistance training, and 5% cold plunges, intermittent fasting, mushroom coffee enemas, tantric meditation, tongue scraping, bee sting therapy, celebrity doctor supplements, and journaling into a fancy Moleskine notebook. Oh, sleep is probably important too.
I don't remember the specifics, but I remember seeing a study saying muscle density is what's tied to better health at older ages. Having stronger muscles around the joints means that they are...
I don't remember the specifics, but I remember seeing a study saying muscle density is what's tied to better health at older ages. Having stronger muscles around the joints means that they are less likely to wear down. I'd imagine there is still some value in cardiovascular health though
Plyometrics are also quite good, if you don't enjoy weight training, some box jumps, medicine ball tosses, etc. have similar benefits when it comes to bone health. Just one easy citation:...
Plyometrics are also quite good, if you don't enjoy weight training, some box jumps, medicine ball tosses, etc. have similar benefits when it comes to bone health.
Interesting -- would love to see what the differences in these cliff years would be depending on location (California vs European, or even Midwest), race, baseline health and diet. Longitudinal...
Interesting -- would love to see what the differences in these cliff years would be depending on location (California vs European, or even Midwest), race, baseline health and diet.
Longitudinal studies are kinda hard to do though, I guess. Hopefully that's something cosmetics/wellness companies have lots of money to tackle.
The study and abstract: https://www.nature.com/articles/s43587-024-00692-2
I dunno if there’s any control on physical fitness.
Certainly the current younger crowd are much more health conscious than before, and things like regular weightlifting mitigate all sorts of age related things.
For example women who don’t weight train can lose bone density quickly in older age, but many more women are now weight lifting to mitigate it.
Its hard to believe that the new lifestyle factors and nutrition knowledge of the current crop of 20-40 year olds isn't markedly different than the current 44-60 year olds, and I am optimistic that any aging cliff around 44 can be fought off with weight lifting and protein rich diets.
This just worries me as someone who prefers cardio to weight training. I figured being active in some way was enough?
I don't know about 'enough' but it is certainly better than nothing. And running does increase bone density as well. I think the best thing for the body may be everything in moderation. That said, as someone who has done periods of both cardio and weight training, the base line of weight training is so much easier than cardio that it is insane. My experience is specifically with programs like Starting Strength and Stronglifts, but doing 5 sets of 5 squats with a barbell is so much easier than running a mile. If you can't manage it, then you're just starting with too much weight.
The way strength incrase works is actually by recruiting additional mitochondria into each muscle cell. This is a process that takes time. My understanding is that once they are there, the structure stays there. So increasing your baseline mitochondria per cell at a younger age is much, much easier. This is likely going to translate to increase longevity.
For good health in age, muscles are paramount: being able to carry stuff, having the leg strength to keep balance, having the core muscles not to gradually hunch more and more forwards, having muscles to lose if I become sick for a period, avoiding breaking things by landing on muscles or having the strength to dampen a fall.
You get the idea. Strength training is extremely important.
I used to bike up hills/mountains 6 days per week during the pandemic. But at some point I threw a frisbee and almost injured my T-rex arms just from flicking my elbow wrong. I realized that having a really strong heart, legs, and lungs isn't covering all of my bases. Sure, I'm not likely to have a heart attack or heart disease as I age on that routine. But I also don't want to lose mobility in an arm because of something stupid.
Muscle is the currency of health. Think of it like a battery, where you want as much muscle mass as you can get while entering old age -- since it's harder to put on and maintain then due to an increasingly shitty deamination process, so you'll have to eat more total overall protein as well compared to when you were twenty years old.
You want this muscle to prevent falls, which are essentially a death sentence/crippling past a certain age. Of the controllable variables, I'd say physical health is 45% diet (maintaining ideal body mass for your sex, height, age, and frame size with about a gram of protein per pound of lean body mass and whatever calories you require to do the stuff you wanna do), 25% cardio, 25% resistance training, and 5% cold plunges, intermittent fasting, mushroom coffee enemas, tantric meditation, tongue scraping, bee sting therapy, celebrity doctor supplements, and journaling into a fancy Moleskine notebook. Oh, sleep is probably important too.
I don't remember the specifics, but I remember seeing a study saying muscle density is what's tied to better health at older ages. Having stronger muscles around the joints means that they are less likely to wear down. I'd imagine there is still some value in cardiovascular health though
Plyometrics are also quite good, if you don't enjoy weight training, some box jumps, medicine ball tosses, etc. have similar benefits when it comes to bone health.
Just one easy citation: https://journals.lww.com/acsm-tj/fulltext/2024/01120/effect_of_plyometrics_on_bone_mineral_density_in.5.aspx
Interesting -- would love to see what the differences in these cliff years would be depending on location (California vs European, or even Midwest), race, baseline health and diet.
Longitudinal studies are kinda hard to do though, I guess. Hopefully that's something cosmetics/wellness companies have lots of money to tackle.