[I'm tagging this as "adult", for purposes of open discussion, with apologies to anyone who may consider the topic inflammatory or sensationalistic.]

Based on discussion of loneliness elsewhere, I'm curious as to what adaptive measures people undertake to promote life satisfaction in the face of environmental/cultural/social stressors.

The word "drug" is used very loosely here, and basically refers to any strategy for purposefully altering neurochemistry - in addition to licit or illicit substance intake, it could be endorphin-boosting exercise, going out with friends, naps, particular reading genres, a good meal, games, direct brain stimulation, meditation, sexual activity, long walks in the country, or whatever.

I'm also taking for granted the proposition that intentionally seeking beneficial neurochemical states is a human activity that everyone participates in, whether they're aware of it or not, and desirable as long as it harms no one.

This is not an attempt to incite, advocate for, or excuse breaking any applicable laws, but a request for information on what people actually do and prefer. If you're concerned about potential legal implications of confessing to an illicit favorite, please discuss in terms of "a friend/someone I know, likes substance/activity x because y".

"Favorite" excludes strategies you've found harmful or destructive, but discussion and/or warning is worthwhile if you feel like it.

I'll start off by saying I have an acquaintance who finds psilocybin micro-dosing very effective at inducing positive emotional balance, mental focus and good sleep regulation.