Has anyone tried it out? There's currently a preventative healthcare initiative going on in my country where they start screening people over 40 for chronic or potentially chronic conditions.

I went for my initial checkup with the doc today and, being juuuuust below morbid obesity with a BMI of 34, asked her about semaglutide as an adjunct to exercise controlling calorie intake. She's referring me to a weight loss clinic at my local public hospital where I can be assessed for suitability (If I'm not mistaken the clinic has hepatologists and endocrinologists on staff along with allied healthcare workers such as physios and nutritionists). This is great because it costs a bomb if I have to go private. The only wrinkle is that I'm oddly enough not diabetic or pre-diabetic so whether or not I'll qualify for socialised semaglutide is unclear but we live in hope.

I was wondering if any of you had tried any of the variants of semaglutide for obesity and what your experiences have been like.

The vaccine antigen technology, developed by the University of Cambridge and spin-out DIOSynVax in early 2020, provided protection against all known variants of SARS-CoV-2 – the virus that causes COVID-19 – as well as other major coronaviruses, including those that caused the first SARS epidemic in 2002.

The studies in mice, rabbits and guinea pigs [...] found that the vaccine candidate provided a strong immune response against a range of coronaviruses by targeting the parts of the virus that are required for replication.

Professor Jonathan Heeney from Cambridge’s Department of Veterinary Medicine, who led the research, [said] “We wanted to come up with a vaccine that wouldn’t only protect against SARS-CoV-2, but all its relatives.”

https://www.eurekalert.org/news-releases/1002345

https://www.nature.com/articles/s41551-023-01094-2

by Wes Davis

A key cold medicine ingredient is basically worthless

The FDA’s 16-member advisory panel unanimously voted yesterday that oral phenylephrine, a common active ingredient in cold medications, is no better than a placebo for treating congestion.

Link to the article

The call by the panel sets up potential FDA action that could force the removal of certain over-the-counter medications containing the ingredient — including certain formulations of Mucinex, Sudafed, Tylenol, and NyQuil — from store shelves.
But FDA may hold off for many months, pending contested findings by drug makers and other considerations.

Data

Newer data from studies the panel says are more consistent with modern clinical trial standards showed phenylephrine simply “was not significantly different from placebo” in the recommended dosage, including trials from 2007 that the FDA had reviewed when considering the drug after a citizen petition prompted it to do so.

Bioavailability

The panel cited the drug’s low bioavailability, a term referring to qualities that allow the drug to be absorbed by the human body, as the main reason the drug should be removed from the market.

Jennifer Schwartzott said the drug “should have been removed from the market a long time ago,” while Dr. Stephen Clement said that although the drug itself isn’t dangerous, its usage by patients should be considered unsafe because it potentially delays actual treatment of disease symptoms.

Alternative

The panel cited pseudoephedrine as an effective alternative though while it’s technically available without a prescription, you must talk to a pharmacist to get it because, in large quantities, it can be used to make methamphetamines.