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    1. Pharmacogenetics personalised medicine: new frontier or nonsense?

      Apparently my private health insurance covers pharmacogenetics testing to find the best ADHD medication. What is it, is it legit? What's the company going to do with my cheek swabs? How do doctors...

      Apparently my private health insurance covers pharmacogenetics testing to find the best ADHD medication. What is it, is it legit? What's the company going to do with my cheek swabs? How do doctors feel about me going up to them and say hey internet pharma bro tells me I should be taking this instead of what your years of medical school thinks.

      What I can't figure out is how my insurance company benefits from this. I'm not paying extra for this service so I must be the product right? Here's part of the marketing FAQ info from my insurance provider:

      Personalized Medicine uses advanced pharmacogenetic testing and pharmacist assistance to find the most effective medication for you.

      If you’re starting a new medication for a mental health condition (such as anxiety or depression), chronic pain, attention deficit hyperactivity disorder (ADHD), or neurological conditions – or taking a medication for one of these conditions and it’s not working or causing side effects – Personalized Medicine could help. It’s offered through your extended health care benefits plan, so the cost of the test may be covered. To see the list of drugs tested, click here.

      It involves a pharmacogenetic test. This is a type of test that identifies how you may respond to medications. Your test results are only for you and anyone you give consent to share them with, such as your doctor. The test is run by Personalized Prescribing Inc., a Canadian company. Manulife

      (Forgot to mention this is for a Canadian employment extended health insurance.)

      15 votes
    2. Midweek Movie Free Talk

      Warning: this post may contain spoilers

      Have you watched any movies recently you want to discuss? Any films you want to recommend or are hyped about? Feel free to discuss anything here.

      Please just try to provide fair warning of spoilers if you can.

      6 votes
    3. Announcing the Backlog Burner event for May 2026: Shrink your unplayed games list this coming month!

      It's almost time... ...for another Backlog Burner -- the event where you try out games you've always wanted to play (but haven't yet -- for whatever reason). The Backlog Burner for May 2026 will...

      It's almost time...

      ...for another Backlog Burner -- the event where you try out games you've always wanted to play (but haven't yet -- for whatever reason).

      The Backlog Burner for May 2026 will officially begin in two days on May 1st.

      If you're new to the Backlog Burner, check out our previous events to get an idea of what's going on:


      Backlog Bingo returns yet again!

      You might notice that the already beautiful Backlog Bingo site has gotten even more beautifuller. That's because our intrepid u/Wes has been hard at work once again adding polish to the site, changing things on the backend to make them smoother and more elegant, and even sprucing up the category lists.

      Backlog Bingo has literally never been better! Or more beautifuller!

      If you participated last time, clear your old card and start fresh with a new one.

      If you're new to the event, click the link above to generate your card (but only if you want to -- playing a bingo card is NOT required to participate).


      Notification List

      If you are interested in participating in the Backlog Burner, please comment in this topic. Anyone commenting/replying here will automatically be added to a notification list for the Backlog Burner, unless you specify otherwise.


      Start Planning (or Playing)

      Technically the event starts in two days, so you have time to roll your cards (if you're playing Bingo) and plan out what you'd like to play for the month. That said, if you're eager to jump right in, and start early, I certainly won't stop you!

      Let's get ready to burn through these backlogs!


      Backlog Burner FAQ

      What exactly is the Backlog Burner?

      Your "backlog" is all those games you've been meaning to play or get around to, but never have yet. This event is an attempt to get us to collectively dig into that treasure trove of experiences, scratch some long-standing itches, and knock a few titles off our to-play lists.

      It runs every May and November. New discussion topics will go up once a week during those months.

      You do not need to sign up in advance -- the topics are open to all. If you would like to be included in the notification list, comment in this topic to be added.

      How do I participate?
      • Choose some games from your backlog and play them.
      • Then tell us about your experiences in the discussion thread for the week.

      That's it!

      Optionally: you can play Backlog Bingo which is a fun way of cutting down the choices you have to make and playing games you might not have normally selected on your own.

      Do I need to finish the games that I play?

      Nope! Not at all.

      There aren't really any requirements for the event so much as this is an incentive to get us to play games we've been avoiding starting up, for whatever reason. Play as much or as little as you like of a given game.

      Try out dozens for ten minutes each or dive into one for 40 hours. There's no wrong way to participate!

      Can I make multiple posts in the same topic?

      Yes! Each discussion thread stays live for a full week, so feel free to make multiple comments in the topic as you play different games. This isn't considered noise -- it's considered valuable participation in the event!


      Backlog Bingo FAQ

      Important: All data for your Backlog Bingo card is stored on your device, not the server. Clearing your browser data will delete your card. You can use the export feature to make backups or move your card between devices.

      I'm a returning player. How do I reset my previous card?

      If you've already created a card and wish to start over, click the Settings button in the header to access your card settings. Then click the Reset button, and confirm the prompt. This will irrevocably delete your present card, allowing you to start fresh.

      Where is my data stored?

      All data is stored by your browser in local storage. There are no accounts, and nothing is sent to the server, so it's privacy-friendly by design. This does mean that you are responsible for not deleting any browser data on wescook.ca, either manually or through automatic cleanups performed on browser close.

      Backlog Bingo is open-source, and licensed permissively under MIT.

      What is the difference between the "Standard" and "Golf" modes?

      In Standard Mode, each square on the bingo card corresponds with one single game. Duplicate games cannot be entered into different squares. A winning card would have a row of five different games that each filled in one square.

      In Golf Mode, duplicates are not only allowed -- they are encouraged! The purpose of Golf mode is to try to find a single game that will fill multiple categories at the same time. For example: Stardew Valley might fulfill You got it on sale, A solo-dev project, and Has romanceable characters all at the same time. A winning card would have all twenty five squares filled, but possibly only six or seven different games.

      What is the star space in the middle?

      That is the "wildcard" or "free space."

      In Standard Mode, there are no requirements to fill it. You can choose any game you want! Anything goes!

      In Golf Mode, it does not need to be filled. Because Golf is all about stacking up categories on a single game, any game used in Golf would fill it automatically, meaning it has no real function. As such, the square will be pre-filled for you if you play in Golf mode.

      The new Free list defaults to having this space turned off. Because you already have full freedom in how you fill the squares, having a free space is redundant (though if you miss it or just like the aesthetics, you can certainly turn it back on!).

      Can I create custom bingo categories for this, or other events?

      Absolutely! The Backlog Bingo app reads in simple JSON files which define the available categories. We've created a couple prebuilt lists for this event, but you're free to tweak our categories, or create completely new ones. You could even use them for books, anime, movies, recipes -- anything!

      If you are interested in learning more, you can find documentation on the wiki, and use an example JSON category file. You can also ask for help in the topic!

      18 votes
    4. TV Tuesdays Free Talk

      Warning: this post may contain spoilers

      Have you watched any TV shows recently you want to discuss? Any shows you want to recommend or are hyped about? Feel free to discuss anything here.

      Please just try to provide fair warning of spoilers if you can.

      5 votes
    5. CGA-2026-04 🕹️🚀🧑‍🚀 REMOVE CARTRIDGE ⏏️ Space Rogue

      Warning: this post may contain spoilers

      Hello there, space rogue! It's time to dock with the mothership, put a glide in your stride and a dip in your hip, and report to us about your adventures.

      Did you play Space Rogue? Did you uncover the mysteries of the universe? Did you conquer Hive? Did you forget to fill in the friendship book? Tell us about your experiences! Or if you didn't play, tell us why this title didn't pique your interest.

      In a couple of days, we will leave behind the life of a pirate, trader and bounty hunter, disembark from the Jolly Roger and hoist the Jolly Roger for a life of a pirate, trader and bounty hunter, this time in Sid Meier's Pirates!, a game so brilliant that it deserves an exclamation mark.

      See you on the salty seas! Or not, if my lookout spots your vessel before yours spots mine, and my master gunner is on top of their game. Arrrr.

      10 votes
    6. Requesting resources for learning Ruby

      Does anyone here have experience with Ruby programming? More specifically mRuby or DragonRuby for game programming? I came across DragonRuby as free for its 7th anniversary and I’m considering...

      Does anyone here have experience with Ruby programming? More specifically mRuby or DragonRuby for game programming?

      I came across DragonRuby as free for its 7th anniversary and I’m considering checking it out, but I have no experience with the Ruby programming language itself.

      Most of my programming experience recently is in C# and Python, but I have some experience with JavaScript/TypeScript.

      Does anyone know of good resources for learning Ruby coming from that background, or thoughts on if it is worth it to try to pick up?

      I’m not really interested in LLM-based Ruby workflows, at least until I have a decent grasp of the language and syntax myself.

      16 votes
    7. Weekly US politics news and updates thread - week of April 27

      This thread is posted weekly - please try to post all relevant US political content in here, such as news, updates, opinion articles, etc. Extremely significant events may warrant a separate...

      This thread is posted weekly - please try to post all relevant US political content in here, such as news, updates, opinion articles, etc. Extremely significant events may warrant a separate topic, but almost all should be posted in here.

      This is an inherently political thread; please try to avoid antagonistic arguments and bickering matches. Comment threads that devolve into unproductive arguments may be removed so that the overall topic is able to continue.

      14 votes
    8. Where can I find the best lanyard?

      I really don't know where to put this, so feel free to move, but I have this issue. I carry a LOT of shit on my keychain. Two sets of keys of four each, a SIM removal tool, a tiny retractable box...

      I really don't know where to put this, so feel free to move, but I have this issue. I carry a LOT of shit on my keychain. Two sets of keys of four each, a SIM removal tool, a tiny retractable box cutter, a USB drive full of installer ISOs (you never know), an AirTag, a CPU with a hole punched through, a 3D printed whistle, and that may very well grow.

      Now the problem I have is that the lanyard that I currently have has, over time, widened the gap on the karabiner to the point that I'll regularly lose a key ring in my pocket when pulling it out. Nothing major's happened yet, but it's a matter of time.

      So, clearly, I need a better one. A higher quality one. But going on the eTailers of today I really only get garbage. A pack of 20! For ten bucks! Well, thanks, but we all know they'll suck. And frankly, I really don't know how to get my hands on a high quality one. I bet they're out there, I'm sure, but where do I look? What's good, what's bad? I really don't need the high-end climbing gear, or do I? Is my key lanyard a candidate for buy it for life, and if so, am I ready for that commitment?

      Looking for any and all advice on this.

      PS: I don't wear the lanyard. I'm one of those assholes that puts the active end in my pocket and lets the lanyard itself dangle out.

      24 votes
    9. What steps can the average user do to secure their data privacy?

      With all of the identity verification laws in the pipeline, data breaches, and government overreach (mandated monitoring in new cars in the US), what steps can the average person take to secure...

      With all of the identity verification laws in the pipeline, data breaches, and government overreach (mandated monitoring in new cars in the US), what steps can the average person take to secure their anonymity and data and device privacy?

      I’m a tech-savvy person but nowhere near the level of a great many. It seems like in the face of overwhelming odds, making small changes is only a drop in the bucket. I have all the data encryption settings enabled on my phone, but I use services like Dropbox and rely on it heavily. I’ve always thought that if the product is free, you’re the product…but I pay for Dropbox, so they shouldn’t use my data for training AI (but they likely are). Setting up a personal cloud seems like a daunting task, as is getting involved in any of the small projects that people have going (decentralized networks, mesh…things, P2P, etc). I’ve focused more on securing my home networks recently so my Ubiquiti devices are restricted in what they can access, but I haven’t actually pen-tested my network yet. I have PopOS! installed on my home desktop because I got tired of Windows’ invasive…everything, but ultimately I don’t know what I’m doing.

      There’s probably a great many people out there that feel like it’s hopeless to try to do anything because it won’t matter as there’s such a heavy push to invade, restrict, and monetize our digital lives. What can the average person do to take control of our devices and data?

      34 votes
    10. Tildes Survey #2: What country do you live in? (Results)

      Original post Submit your response here! Direct link: https://survey.tildes.community/form/what-country-do-you-live-in-2 This survey closes on May 3, 2026 at 10:00 UTC The results will be...
      Original post

      Submit your response here!


      The current plans for questions that will be asked in the coming weeks are as follows:

      Question Survey opens Survey closes
      How old are you? 2026-04-19 18:00 UTC 2026-04-26 10:00 UTC
      What country do you live in? 2026-04-26 18:00 UTC 2026-05-03 10:00 UTC
      What country were you born in? 2026-05-03 18:00 UTC 2026-05-10 10:00 UTC
      What languages can you speak? 2026-05-10 18:00 UTC 2026-05-17 10:00 UTC

      Please submit your ideas for questions here! Even if they've been submitted already by someone else. All input is valuable! You can view all submitted questions on this dashboard.


      Thank you all for participating!

      The survey has been closed and the results are in!

      Thank you to all the 244 people that responded! Check out the dashboard for a map visualization and a breakdown per continent, region and country! Here's a few quick stats:

      • 43 distinct countries are represented!
      • Spread across the following continents:
        • America at 48.5%
        • Europe at 39.0%
        • Asia at 6.2%
        • Oceania at 5.8%
        • Africa at 0.4%
      • And the top 5 countries with the most responses:
        • United States at 37.7%
        • Canada at 8.2%
        • United Kingdom at 8.2%
        • Germany at 4.9%
        • Netherlands at 4.9%

      Thank you all again for participating! I hope to see you in the next survey. :)

      56 votes