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    1. Pharmacogenetics personalised medicine: new frontier or nonsense?

      Apparently my private health insurance covers pharmacogenetics testing to find the best ADHD medication. What is it, is it legit? What's the company going to do with my cheek swabs? How do doctors...

      Apparently my private health insurance covers pharmacogenetics testing to find the best ADHD medication. What is it, is it legit? What's the company going to do with my cheek swabs? How do doctors feel about me going up to them and say hey internet pharma bro tells me I should be taking this instead of what your years of medical school thinks.

      What I can't figure out is how my insurance company benefits from this. I'm not paying extra for this service so I must be the product right? Here's part of the marketing FAQ info from my insurance provider:

      Personalized Medicine uses advanced pharmacogenetic testing and pharmacist assistance to find the most effective medication for you.

      If you’re starting a new medication for a mental health condition (such as anxiety or depression), chronic pain, attention deficit hyperactivity disorder (ADHD), or neurological conditions – or taking a medication for one of these conditions and it’s not working or causing side effects – Personalized Medicine could help. It’s offered through your extended health care benefits plan, so the cost of the test may be covered. To see the list of drugs tested, click here.

      It involves a pharmacogenetic test. This is a type of test that identifies how you may respond to medications. Your test results are only for you and anyone you give consent to share them with, such as your doctor. The test is run by Personalized Prescribing Inc., a Canadian company. Manulife

      (Forgot to mention this is for a Canadian employment extended health insurance.)

      8 votes
    2. Announcing the Backlog Burner event for May 2026: Shrink your unplayed games list this coming month!

      It's almost time... ...for another Backlog Burner -- the event where you try out games you've always wanted to play (but haven't yet -- for whatever reason). The Backlog Burner for May 2026 will...

      It's almost time...

      ...for another Backlog Burner -- the event where you try out games you've always wanted to play (but haven't yet -- for whatever reason).

      The Backlog Burner for May 2026 will officially begin in two days on May 1st.

      If you're new to the Backlog Burner, check out our previous events to get an idea of what's going on:


      Backlog Bingo returns yet again!

      You might notice that the already beautiful Backlog Bingo site has gotten even more beautifuller. That's because our intrepid u/Wes has been hard at work once again adding polish to the site, changing things on the backend to make them smoother and more elegant, and even sprucing up the category lists.

      Backlog Bingo has literally never been better! Or more beautifuller!

      If you participated last time, clear your old card and start fresh with a new one.

      If you're new to the event, click the link above to generate your card (but only if you want to -- playing a bingo card is NOT required to participate).


      Notification List

      If you are interested in participating in the Backlog Burner, please comment in this topic. Anyone commenting/replying here will automatically be added to a notification list for the Backlog Burner, unless you specify otherwise.


      Start Planning (or Playing)

      Technically the event starts in two days, so you have time to roll your cards (if you're playing Bingo) and plan out what you'd like to play for the month. That said, if you're eager to jump right in, and start early, I certainly won't stop you!

      Let's get ready to burn through these backlogs!


      Backlog Burner FAQ

      What exactly is the Backlog Burner?

      Your "backlog" is all those games you've been meaning to play or get around to, but never have yet. This event is an attempt to get us to collectively dig into that treasure trove of experiences, scratch some long-standing itches, and knock a few titles off our to-play lists.

      It runs every May and November. New discussion topics will go up once a week during those months.

      You do not need to sign up in advance -- the topics are open to all. If you would like to be included in the notification list, comment in this topic to be added.

      How do I participate?
      • Choose some games from your backlog and play them.
      • Then tell us about your experiences in the discussion thread for the week.

      That's it!

      Optionally: you can play Backlog Bingo which is a fun way of cutting down the choices you have to make and playing games you might not have normally selected on your own.

      Do I need to finish the games that I play?

      Nope! Not at all.

      There aren't really any requirements for the event so much as this is an incentive to get us to play games we've been avoiding starting up, for whatever reason. Play as much or as little as you like of a given game.

      Try out dozens for ten minutes each or dive into one for 40 hours. There's no wrong way to participate!

      Can I make multiple posts in the same topic?

      Yes! Each discussion thread stays live for a full week, so feel free to make multiple comments in the topic as you play different games. This isn't considered noise -- it's considered valuable participation in the event!


      Backlog Bingo FAQ

      Important: All data for your Backlog Bingo card is stored on your device, not the server. Clearing your browser data will delete your card. You can use the export feature to make backups or move your card between devices.

      I'm a returning player. How do I reset my previous card?

      If you've already created a card and wish to start over, click the Settings button in the header to access your card settings. Then click the Reset button, and confirm the prompt. This will irrevocably delete your present card, allowing you to start fresh.

      Where is my data stored?

      All data is stored by your browser in local storage. There are no accounts, and nothing is sent to the server, so it's privacy-friendly by design. This does mean that you are responsible for not deleting any browser data on wescook.ca, either manually or through automatic cleanups performed on browser close.

      Backlog Bingo is open-source, and licensed permissively under MIT.

      What is the difference between the "Standard" and "Golf" modes?

      In Standard Mode, each square on the bingo card corresponds with one single game. Duplicate games cannot be entered into different squares. A winning card would have a row of five different games that each filled in one square.

      In Golf Mode, duplicates are not only allowed -- they are encouraged! The purpose of Golf mode is to try to find a single game that will fill multiple categories at the same time. For example: Stardew Valley might fulfill You got it on sale, A solo-dev project, and Has romanceable characters all at the same time. A winning card would have all twenty five squares filled, but possibly only six or seven different games.

      What is the star space in the middle?

      That is the "wildcard" or "free space."

      In Standard Mode, there are no requirements to fill it. You can choose any game you want! Anything goes!

      In Golf Mode, it does not need to be filled. Because Golf is all about stacking up categories on a single game, any game used in Golf would fill it automatically, meaning it has no real function. As such, the square will be pre-filled for you if you play in Golf mode.

      The new Free list defaults to having this space turned off. Because you already have full freedom in how you fill the squares, having a free space is redundant (though if you miss it or just like the aesthetics, you can certainly turn it back on!).

      Can I create custom bingo categories for this, or other events?

      Absolutely! The Backlog Bingo app reads in simple JSON files which define the available categories. We've created a couple prebuilt lists for this event, but you're free to tweak our categories, or create completely new ones. You could even use them for books, anime, movies, recipes -- anything!

      If you are interested in learning more, you can find documentation on the wiki, and use an example JSON category file. You can also ask for help in the topic!

      13 votes
    3. CGA-2026-04 🕹️🚀🧑‍🚀 REMOVE CARTRIDGE ⏏️ Space Rogue

      Warning: this post may contain spoilers

      Hello there, space rogue! It's time to dock with the mothership, put a glide in your stride and a dip in your hip, and report to us about your adventures.

      Did you play Space Rogue? Did you uncover the mysteries of the universe? Did you conquer Hive? Did you forget to fill in the friendship book? Tell us about your experiences! Or if you didn't play, tell us why this title didn't pique your interest.

      In a couple of days, we will leave behind the life of a pirate, trader and bounty hunter, disembark from the Jolly Roger and hoist the Jolly Roger for a life of a pirate, trader and bounty hunter, this time in Sid Meier's Pirates!, a game so brilliant that it deserves an exclamation mark.

      See you on the salty seas! Or not, if my lookout spots your vessel before yours spots mine, and my master gunner is on top of their game. Arrrr.

      8 votes
    4. I love bioparks

      I recently visited Albuquerque and spent almost a full day at their botanical gardens. It was awesome and made realize how much I love bioparks. Of all the attractions a city may have, they always...

      I recently visited Albuquerque and spent almost a full day at their botanical gardens. It was awesome and made realize how much I love bioparks.
      Of all the attractions a city may have, they always delight and never leave me conflicted like I feel at zoos and aquariums.

      So I ask the people of Tides: where are the best bio parks and what makes them great?

      13 votes
    5. TV Tuesdays Free Talk

      Warning: this post may contain spoilers

      Have you watched any TV shows recently you want to discuss? Any shows you want to recommend or are hyped about? Feel free to discuss anything here.

      Please just try to provide fair warning of spoilers if you can.

      4 votes
    6. What steps can the average user do to secure their data privacy?

      With all of the identity verification laws in the pipeline, data breaches, and government overreach (mandated monitoring in new cars in the US), what steps can the average person take to secure...

      With all of the identity verification laws in the pipeline, data breaches, and government overreach (mandated monitoring in new cars in the US), what steps can the average person take to secure their anonymity and data and device privacy?

      I’m a tech-savvy person but nowhere near the level of a great many. It seems like in the face of overwhelming odds, making small changes is only a drop in the bucket. I have all the data encryption settings enabled on my phone, but I use services like Dropbox and rely on it heavily. I’ve always thought that if the product is free, you’re the product…but I pay for Dropbox, so they shouldn’t use my data for training AI (but they likely are). Setting up a personal cloud seems like a daunting task, as is getting involved in any of the small projects that people have going (decentralized networks, mesh…things, P2P, etc). I’ve focused more on securing my home networks recently so my Ubiquiti devices are restricted in what they can access, but I haven’t actually pen-tested my network yet. I have PopOS! installed on my home desktop because I got tired of Windows’ invasive…everything, but ultimately I don’t know what I’m doing.

      There’s probably a great many people out there that feel like it’s hopeless to try to do anything because it won’t matter as there’s such a heavy push to invade, restrict, and monetize our digital lives. What can the average person do to take control of our devices and data?

      31 votes
    7. Midweek Movie Free Talk

      Warning: this post may contain spoilers

      Have you watched any movies recently you want to discuss? Any films you want to recommend or are hyped about? Feel free to discuss anything here.

      Please just try to provide fair warning of spoilers if you can.

      4 votes
    8. Requesting resources for learning Ruby

      Does anyone here have experience with Ruby programming? More specifically mRuby or DragonRuby for game programming? I came across DragonRuby as free for its 7th anniversary and I’m considering...

      Does anyone here have experience with Ruby programming? More specifically mRuby or DragonRuby for game programming?

      I came across DragonRuby as free for its 7th anniversary and I’m considering checking it out, but I have no experience with the Ruby programming language itself.

      Most of my programming experience recently is in C# and Python, but I have some experience with JavaScript/TypeScript.

      Does anyone know of good resources for learning Ruby coming from that background, or thoughts on if it is worth it to try to pick up?

      I’m not really interested in LLM-based Ruby workflows, at least until I have a decent grasp of the language and syntax myself.

      16 votes
    9. Tildes Minecraft Weekly

      Server host: tildes.nore.gg (Running Java 1.21.11) Verification site: https://tildes.nore.gg BlueMap: https://tildes.nore.gg/map/ Patreon: https://www.patreon.com/TildesMC Plugins and Data Packs...

      Server host: tildes.nore.gg (Running Java 1.21.11)
      Verification site: https://tildes.nore.gg
      BlueMap: https://tildes.nore.gg/map/
      Patreon: https://www.patreon.com/TildesMC

      Plugins and Data Packs Data Packs:
      • Terralith - Overworld terrain upgrade
      • Nullscape - End terrain upgrade
      • Age Lock [Vanilla Tweaks]
      • Armor Statues [Vanilla Tweaks]
      • Bat Membranes [Vanilla Tweaks]
      • Cauldron Concrete [Vanilla Tweaks]
      • Cauldron Mud [Vanilla Tweaks]
      • Custom Nether Portals [Vanilla Tweaks]
      • Husks Drop Sand [Vanilla Tweaks]
      • Mini Blocks [Vanilla Tweaks]
      • More Mob Heads [Vanilla Tweaks]
      • Player Head Drops [Vanilla Tweaks]
      • Silence Mobs [Vanilla Tweaks]
      • Wandering Trades [Vanilla Tweaks]

      Plugins:

      • BlueMap - Provides a live 3D rendering of the game world
      • Clickable Links - Makes http URLs in chat clickable (only for registered players)
      • CoreProtect - Records all block/container/mob changes (Anyone can look up changes with /co inspect)
      • DebugStick - Gives the ability to craft debug sticks in survival
      • DistantHorizons - Provides distant LOD map data to players running the client mod
      • EasyArmorStands - GUI for editing armor stands
      • Hexnicks - Enables Tildes usernames to be displayed
      • hsrails - Allows for 4x speed rail travel
      • LuckPerms - Locks down unregistered users
      • Otherside - Fix for mob farms involving Nether portals
      • Rapid Leaf Decay - Increases the speed of leaf decay by 10x
      • WorldEdit - Used for occasional admin stuff
      • WorldGuard - Prevents unregistered users from changing anything in the world

      The server operates on a soft whitelist. Anyone can log in and walk around, but you need a Tildes account to gain build access.


      We recommend you install our mod web-chat so that you can chat while in your web browser. It turns the server into an old-school chat room.

      <- Previous Thread

      16 votes
    10. Tildes Survey #2: What country do you live in?

      Submit your response here! Direct link: https://survey.tildes.community/form/what-country-do-you-live-in-2 This survey closes on May 3, 2026 at 10:00 UTC The results will be published on May 3...

      Submit your response here!


      The current plans for questions that will be asked in the coming weeks are as follows:

      Question Survey opens Survey closes
      How old are you? 2026-04-19 18:00 UTC 2026-04-26 10:00 UTC
      What country do you live in? 2026-04-26 18:00 UTC 2026-05-03 10:00 UTC
      What country were you born in? 2026-05-03 18:00 UTC 2026-05-10 10:00 UTC
      What languages can you speak? 2026-05-10 18:00 UTC 2026-05-17 10:00 UTC

      Please submit your ideas for questions here! Even if they've been submitted already by someone else. All input is valuable! You can view all submitted questions on this dashboard.


      Thank you all again for participating! <3

      49 votes
    11. Offbeat Fridays – The thread where offbeat headlines become front page news

      Tildes is a very serious site, where we discuss very serious matters like lists, thanksgiving and sexploitation. Tags culled from the highest voted topics from the last seven days, if anyone was...

      Tildes is a very serious site, where we discuss very serious matters like lists, thanksgiving and sexploitation. Tags culled from the highest voted topics from the last seven days, if anyone was bemused.

      But one of my favourite tags happens to be offbeat! Taking its original inspiration from Sir Nils Olav III, this thread is looking for any far-fetched offbeat stories lurking in the newspapers. It may not deserve its own post, but it deserves a wider audience!

      8 votes
    12. Where can I find the best lanyard?

      I really don't know where to put this, so feel free to move, but I have this issue. I carry a LOT of shit on my keychain. Two sets of keys of four each, a SIM removal tool, a tiny retractable box...

      I really don't know where to put this, so feel free to move, but I have this issue. I carry a LOT of shit on my keychain. Two sets of keys of four each, a SIM removal tool, a tiny retractable box cutter, a USB drive full of installer ISOs (you never know), an AirTag, a CPU with a hole punched through, a 3D printed whistle, and that may very well grow.

      Now the problem I have is that the lanyard that I currently have has, over time, widened the gap on the karabiner to the point that I'll regularly lose a key ring in my pocket when pulling it out. Nothing major's happened yet, but it's a matter of time.

      So, clearly, I need a better one. A higher quality one. But going on the eTailers of today I really only get garbage. A pack of 20! For ten bucks! Well, thanks, but we all know they'll suck. And frankly, I really don't know how to get my hands on a high quality one. I bet they're out there, I'm sure, but where do I look? What's good, what's bad? I really don't need the high-end climbing gear, or do I? Is my key lanyard a candidate for buy it for life, and if so, am I ready for that commitment?

      Looking for any and all advice on this.

      PS: I don't wear the lanyard. I'm one of those assholes that puts the active end in my pocket and lets the lanyard itself dangle out.

      23 votes
    13. Tildes Book Club discussion - April 2026 - The Tea Girl of Hummingbird Lane by Lisa See

      Warning: this post may contain spoilers

      This is the fourth Tildes Book Club Discussion for 2026 and the twenty-fourth overall. We are discussing The Tea Girl of Hummingbird Lane by Lisa See. For May, we will discuss Pnin by Vladimir Nabokov.

      I don't have a particular format in mind for this discussion, but I will post some prompts and questions as comments to get things started. You're not obligated to respond to them or vote on them though. So feel free to make your own top-level comment for whatever you wish to discuss, questions you have of others, or even just to post a review of the book you have written yourself.

      For latecomers, don't worry if you didn't read the book in time for this Discussion topic. You can always join in once you finish it. Tildes Activity sort, and "Collapse old comments" feature should keep the topic going for as long as people are still replying.

      And for anyone uninterested in this topic please use the Ignore Topic feature on this so it doesn't keep popping up in your Activity sort, since it's likely to keep doing that while I set this discussion up, and once people start joining in.

      10 votes